Systematic Analysis of Risk Factors for Coronary Heart Disease in Japanese Patients with Type 2 Diabetes: A Matched Case-Control Study

Fumisawa, Y; Funase, Yoshiko; Yamashita, Koh; Yamauchi, Kazuyo; Miyamoto, Takahide; Tsunemoto, Hideo; Sakurai, Shunpei; Aizawa, Toru

doi:10.5551/jat.13334

Cited by 8 publications

(4 citation statements)

References 26 publications

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“…However, in our study, no significant difference was found in BMI between the Japanese CAD(−) and CAD(+) patients. In the report by Fumisawa et al [ 26 ], there was no difference in BMI between Japanese CAD patients and age- and sex-matched controls. Saito et al [ 27 ] also reported that obesity was not an independent factor for CAD among 38,385 Japanese patients without prior CAD.…”

Section: Discussionmentioning

confidence: 89%

High Plasma Levels of Fortilin in Patients with Coronary Artery Disease

Aoyama

Kishimoto

Saita

et al. 2022

IJMS

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Excessive apoptosis is known to be a common feature of atherosclerotic lesions. Fortilin is recognized to have potent antiapoptotic properties. An increased fortilin expression was demonstrated in atherosclerotic lesions, and fortilin knockout mice developed less atherosclerosis. However, no study has reported blood fortilin levels in patients with coronary artery disease (CAD). We investigated plasma fortilin levels in 384 patients undergoing coronary angiography. CAD severity was evaluated as the numbers of stenotic vessels and segments. CAD was found in 208 patients (one-vessel (1VD), n = 86; two-vessel (2VD), n = 68; and three-vessel disease (3VD), n = 53). Plasma C-reactive protein (CRP) levels were higher in patients with CAD than without CAD (median 0.60 vs. 0.45 mg/L, p < 0.01). Notably, fortilin levels were higher in patients with CAD than without CAD (75.1 vs. 69.7 pg/mL, p < 0.02). A stepwise increase in fortilin was found according to the number of stenotic vessels: 69.7 in CAD(−), 71.1 in 1VD, 75.7 in 2VD, and 84.7 pg/mL in 3VD (p < 0.01). Fortilin levels also correlated with the number of stenotic segments (r = 0.16) and CRP levels (r = 0.24) (p < 0.01). In a multivariate analysis, fortilin levels were independently associated with 3VD. The odds ratio for 3VD was 1.93 (95%CI = 1.01–3.71) for a high fortilin level (>70.0 pg/mL). Thus, plasma fortilin levels in patients with CAD, especially those with 3VD, were found to be high and to be associated with the severity of CAD.

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Section: Discussionmentioning

confidence: 89%

High Plasma Levels of Fortilin in Patients with Coronary Artery Disease

Aoyama

Kishimoto

Saita

et al. 2022

IJMS

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“…The optimal cut-off value was found to be 3.62 mmol/L (140 mg/dl) (41). Among Japanese patients with type 2 diabetes, the threshold of non-HDL-C was 3.89 mmol/L (31).…”

Section: Discussionmentioning

confidence: 93%

Association of Elevated Non-HDL-C and LDL-C with Carotid atherosclerosis among Tibetans Living at High Altitudes: A Cross-sectional Study

Zhang

Gou

et al. 2022

Preprint

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Background: Hypoxic circumstances impair endothelial function and may contribute to carotid atherosclerosis. In high-altitude areas, there is a scarcity of data on the correlation between lipid particles and carotid atherosclerosis. Methods: A total of 587 patients who underwent carotid artery ultrasound and met the inclusion and exclusion criteria were enrolled in our cross-sectional study. All participants resided in Luhuo County, Ganzi Tibetan Autonomous Prefecture, Sichuan Province, China (mean altitude: 3,860 meters). We used questionnaires, physical examination, blood sample testing, and ultrasound in our investigation. Spearman correlation analysis and multiple linear regression analysis were performed to explore the association between lipid particles and carotid atherosclerosis. We compared the disparity between lipid particles in predicting atherosclerosis using the receiver operator characteristic curve.Results: We found a statistically significant association between lipid particles and carotid atherosclerosis. After adjustment for certain variables, including age, gender, mean arterial pressure, and fasting blood glucose, we discovered that non-high-density lipoprotein-cholesterol (non-HDL-C) was a risk factor for carotid intima-media thickness (β = 0.012, p = 0.032) but not for low-density lipoprotein cholesterol (LDL-C) (p = 0.073). In terms of lifestyle, non-HDL-C was also found to be a risk factor for atherosclerosis independent of cigarette smoking and vegetarian (β = 0.012, p = 0.049). The area under the curve (AUC) of non-HDL-C was 0.644 (CI: 0.583 – 0.706) while LDL-C was 0.599 (CI: 0.534 - 0.664) in predicting carotid atherosclerosis. The optimal cut-off value of non-HDL-C was 3.625 mmol/L in predicting carotid plaques. Conclusions: Among Tibetans living in high-altitude areas, non-HDL-C is a better biomarker than LDL-C for carotid artery atherosclerosis independent of conventional risk factors. It is crucial to resolve non-HDL-C dyslipidemia in order to mitigate carotid atherosclerosis in Tibetans living at high-altitude settings.

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“…The NonHDLc/HDLc ratio captures atherogenic lipid abnormalities other than LDLc including abnormalities in lipid particles such as small dense LDL, very low-density lipoproteins (VLDL), and HDLc similarly to that of ApoB/A1 [9]. Accordingly, the NonHDLc/HDLc ratio had a stronger association with CHD risk than LDLc, HDL-cholesterol or non-HDL-cholesterol [11,20,21]. Our research described here extends findings that the NonHDLc/HDLc ratio not only is associated with CHD but also with the development of CKD.…”

Section: Discussionmentioning

confidence: 93%

Non-HDL-cholesterol to HDL-cholesterol ratio as an independent risk factor for the development of chronic kidney disease

Zuo¹,

Chen²,

Liu

et al. 2015

Nutrition, Metabolism and Cardiovascular Diseases

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Systematic Analysis of Risk Factors for Coronary Heart Disease in Japanese Patients with Type 2 Diabetes: A Matched Case-Control Study

Abstract: Aim: To identify predictors of coronary heart disease (CHD) in Japanese patients with type 2 diabetes (T2DM).Methods: A matched case-control study was performed using 800 patients with T2DM admitted for treatment of hyperglycemia from January

Cited by 8 publications

References 26 publications

High Plasma Levels of Fortilin in Patients with Coronary Artery Disease

High Plasma Levels of Fortilin in Patients with Coronary Artery Disease

Association of Elevated Non-HDL-C and LDL-C with Carotid atherosclerosis among Tibetans Living at High Altitudes: A Cross-sectional Study

Non-HDL-cholesterol to HDL-cholesterol ratio as an independent risk factor for the development of chronic kidney disease

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