Systematic analysis of post-treatment soft-tissue edema and seroma on MRI in 177 sarcoma patients

Sedaghat, Sam; Schmitz, Frederick; Meschede, Jens; Sedaghat, Maya

doi:10.1016/j.suronc.2020.08.023

Cited by 12 publications

(11 citation statements)

References 20 publications

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“…In our experience, the combination of small lesions and postoperative edema of the surrounding soft tissue renders postoperative MRI surveillance challenging. Although it is already known that radiation therapy causes an increased rate of soft tissue edema [31], post-radiation changes have no significant influence on the diagnostic accuracy in our study. Nevertheless, our experience shows that post-radiation changes make the detection of recurrences more difficult.…”

Section: Discussioncontrasting

confidence: 55%

Long-term diagnostic value of MRI in detecting recurrent aggressive fibromatosis at two multidisciplinary sarcoma centers

Sedaghat

Krohn³

et al. 2021

European Journal of Radiology

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To assess the diagnostic accuracy of MRI in detecting recurrent aggressive fibromatosis (AF) during longterm follow-up at two multidisciplinary sarcoma centers. Methods: Seventy-nine patients from two sarcoma centers were included in this IRB-approved study and were examined postoperatively using 1.5-T MRI. MRI follow-up scans were reviewed for true-positive/-negative and false-positive/-negative results. Available pathological reports and MRI follow-ups were set as reference. Results: The median age of the patients was 38.1 ± 15.3 years. Of the patients 27.9 % showed recurrent AF lesions. The most common localizations of AF were the axilla/shoulder (n = 15) and the thigh (n = 11). From 498 postoperative MRI follow-ups, 24 true-positive, 16 false-positive, 6 false-negative, and 452 true-negative MRI follow-ups were identified. The overall sensitivity and specificity for detecting recurrent AF was 80 % and 97 %, respectively. There was no significant difference in the diagnostic accuracy at the two sarcoma centers. All falsenegative results were found in small lesions. False-positive results mostly mimicked streaky (n = 10) and small ovoid/nodular (n = 5) lesions. The configuration of recurrent AF was significantly most often fascicular (50 %; p = 0.001− 0.005). Conclusion: MRI shows a high long-term diagnostic value in detecting AF recurrences. Nevertheless, radiologists should pay close attention when lesions are small, as they may remain undetected. Although the configuration of recurrent AF is most often fascicular, recurrences may also appear in different shapes.

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Section: Discussioncontrasting

confidence: 55%

Long-term diagnostic value of MRI in detecting recurrent aggressive fibromatosis at two multidisciplinary sarcoma centers

Sedaghat

Krohn³

et al. 2021

European Journal of Radiology

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“…Previous studies show that the grade of loco-regional soft-tissue edema correlates with the type of therapy. Correspondingly, marked soft-tissue edema is significantly associated with radiation therapy (24). In the present study, high-grade edema is also linked to radiation therapy.…”

Section: Discussionmentioning

confidence: 99%

Does the primary soft-tissue sarcoma configuration predict configuration of recurrent tumors on magnetic resonance imaging?

et al. 2021

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Background Soft-tissue sarcomas (STS) are rare malignancies of the soft tissue. Purpose To assess whether the magnetic resonance imaging (MRI) configuration of primary STS can predict the configuration of a recurring tumor and whether the MRI configuration of multiple recurrences differs in one and the same patient. Material and Methods Thirty-nine patients with histologically proven recurrent STS were included in this retrospective study and underwent pre- and post-treatment MRI. Three main configurations of primary and recurrent tumors were identified: polycyclic/multilobulated; ovoid/nodular; and streaky. Results Sixty recurrent lesions were detected: 34 ovoid/nodular; 15 polycyclic/multilobulated; and 11 streaky. Five recurrences were multifocal and eight were bifocal. Of 39 patients, 28 (71.8%) presented one recurrence within the MRI follow-up period ( P = 0.006); in 10 patients (25.6%), up to three different configurations of recurring STS were identified in one patient. Recurrences of polycyclic/multilobulated primaries were mostly ovoid/nodular (48%; P = 0.003) or polycyclic/multilobulated (37%; P = 0.014), and recurring ovoid/nodular STS significantly most often showed the same configuration as the primary tumor (85%; P < 0.001). Primary STS with a streaky configuration recurred in all three configurations in roughly equal proportions. Homogeneity/heterogeneity and tumor borders are significantly associated with the configuration of recurrences. Conclusion Primary STS configuration may help predict recurrent tumor configuration when the primary STS had a polycyclic/multilobulated or ovoid/nodular configuration. However, recurrent STS configuration can also differ from primary STS configuration, especially when the primary STS had a streaky configuration, rendering recurrent STS difficult to predict. Different configurations of recurrent STS in one and the same patient are common.

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“…Ultrasound is often the first-approach modality, but MRI is mandatory to characterize the lesion, assess its anatomical limits and therefore guide treatment decision [ 3 ]. Also, some STS features seen on MRI may predict the grade of malignancy of the lesions [ 62 ], recurrences [ 63 , 64 ], post-treatment oedema and seroma [ 65 ]. Thoracic CT or PET-CT are used to assess secondary lesions.…”

Section: Discussionmentioning

confidence: 99%

The impact of radiomics in the management of soft tissue sarcoma

De Angelis,

Casale,

Coquelet

et al. 2024

Discov Onc

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Introduction Soft tissue sarcomas (STSs) are rare malignancies. Pre-therapeutic tumour grading and assessment are crucial in making treatment decisions. Radiomics is a high-throughput method for analysing imaging data, providing quantitative information beyond expert assessment. This review highlights the role of radiomic texture analysis in STSs evaluation. Materials and methods We conducted a systematic review according to the Systematic Reviews and Meta-Analyses (PRISMA) guidelines. A comprehensive search was conducted in PubMed/MEDLINE and Scopus using the search terms: ‘radiomics [All Fields] AND ("soft tissue sarcoma" [All Fields] OR "soft tissue sarcomas" [All Fields])’. Only original articles, referring to humans, were included. Results A preliminary search conducted on PubMed/MEDLINE and Scopus provided 74 and 93 studies respectively. Based on the previously described criteria, 49 papers were selected, with a publication range from July 2015 to June 2023. The main domains of interest were risk stratification, histological grading prediction, technical feasibility/reproductive aspects, treatment response. Conclusions With an increasing interest over the last years, the use of radiomics appears to have potential for assessing STSs from initial diagnosis to predicting treatment response. However, additional and extensive research is necessary to validate the effectiveness of radiomics parameters and to integrate them into a comprehensive decision support system.

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Systematic analysis of post-treatment soft-tissue edema and seroma on MRI in 177 sarcoma patients

Cited by 12 publications

References 20 publications

Long-term diagnostic value of MRI in detecting recurrent aggressive fibromatosis at two multidisciplinary sarcoma centers

Long-term diagnostic value of MRI in detecting recurrent aggressive fibromatosis at two multidisciplinary sarcoma centers

Does the primary soft-tissue sarcoma configuration predict configuration of recurrent tumors on magnetic resonance imaging?

The impact of radiomics in the management of soft tissue sarcoma

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