Systematic analyses on the potential immune and anti-inflammatory mechanisms of Shufeng Jiedu Capsule against Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2)-caused pneumonia

Tao, Zhengang; Zhang, Lei; Friedemann, Thomas; Yang, Guowei; Li, Jinhu; Wen, Yaocai; Wang, Jinghui; Shen, Adong

doi:10.1016/j.jff.2020.104243

Cited by 22 publications

(17 citation statements)

References 49 publications

(61 reference statements)

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“…According to sequence alignment and homology modeling, the critical targets of spike, 3C-like protease (3CLpro), papain-like protease (PLpro), and RNA-dependent RNA polymerase (RdRp) protease share 76%, 96%, 83%, 96% sequence similarity between SARS-CoV and SARS-CoV-2, respectively 85 , 86 , 87 . We collected and summarized TCMs and their ingredients to reveal the specific mechanisms of TCM for the three phases of distinct disease stages of COVID-19 42 , 88 , 89 , 90 , 91 , 92 , 93 , 94 , 95 , 96 , 97 , 98 , 99 , 100 , 101 , 102 , 103 , 104 , 105 , 106 , 107 , 108 , 109 , 110 , 111 , 112 , 113 , 114 , 115 , 116 , 117 , 118 , 119 , 120 , 121 , 122 , 123 , 124 , 125 , 126 , 127 , 128 , 129 , 130 , 131 , 132 , 133 , 134 , 135 , 136 , 137 , 138 , 139 , 140 , 141 , 142 , 143 , 144 , 145 , 146 , 147 , …”

Section: Potential Mechanisms Of Tcm For Covid-19mentioning

confidence: 99%

Traditional Chinese medicine in COVID-19

Lyu

Fan

Xiao

et al. 2021

Acta Pharmaceutica Sinica B

135

118

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COVID-19 pandemic caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has spread across the globe, posing an enormous threat to public health and safety. Traditional Chinese medicine (TCM), in combination with Western medicine (WM), has made important and lasting contributions in the battle against COVID-19. In this review, updated clinical effects and potential mechanisms of TCM, presented in newly recognized three distinct phases of the disease, are summarized and discussed. By integrating the available clinical and preclinical evidence, the efficacies and underlying mechanisms of TCM on COVID-19, including the highly recommended three Chinese patent medicines and three Chinese medicine formulas, are described in a panorama. We hope that this comprehensive review not only provides a reference for health care professionals and the public to recognize the significant contributions of TCM for COVID-19, but also serves as an evidence-based in-depth summary and analysis to facilitate understanding the true scientific value of TCM.

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Section: Potential Mechanisms Of Tcm For Covid-19mentioning

confidence: 99%

Traditional Chinese medicine in COVID-19

Lyu

Fan

Xiao

et al. 2021

Acta Pharmaceutica Sinica B

135

118

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“…Of these innovative prescriptions, Shufeng Jiedu Jiaonang (疏风解毒胶囊)-Sofugedokukono (疏風解毒膠囊) in Japanese-has proven especially effective and has also entered the Chinese national treatment guidelines for COVID-19. In preclinical studies immunomodulatory and anti-inflammatory effects have been shown against severe actue respiratory syndrom SARS-CoV2-caused pneumonia (Tao et al 2020). Clinical studies are on their way (Xia et al 2020;Chen et al 2021) (Table 5).…”

Section: Anti-viral Activity Of Kampo Prescriptions Such As Maotomentioning

confidence: 99%

Which East Asian herbal medicines can decrease viral infections?

et al. 2021

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Whilst Western research for the COVID-19 crisis focuses on vaccination, in East Asia traditional herbal prescriptions are studied for SARS-CoV2 therapy. In Japan, Maoto (Ephedrae herba 4 g, Armeniacae semen 4 g, Cinnamomi cortex 3 g, and Glycyrrhizae radix 2 g, JPXVII) is used based on clinical evidence for its effect on early phase influenza (also caused by RNA viruses) comparable to that of oseltamivir. The Health Ministry of Thailand has approved Andrographis paniculata (Jap. Senshinren) extracts for treatment of COVID-19. Its combination (4 g) with Maoto, Maoto-ka-senshinren, seems most promising for the treatment of viral pandemics. In China, the official guideline for COVID-19 treatment contains TCM medications with antiviral, as well as immunmodulatory and anti-inflammatory effects such as: Qing-Fei-Pai-Du-Tang (Jap. Seihai-haidokuto) contains 21 drugs; Shufeng Jiedu Jiaonang (Bupleuri radix 8 g, Forsythiae fructus 8 g, Glycyrrhizae radix 4 g, Isatidis radix 8 g, Patriniae herba 8 g, Phragmitis rhizoma 6 g, Polygoni cuspidati rhizoma 10 g, Verbenae herba 8 g); Fufang Yuxingcao Heiji (Forsythiae fructus 0.6 g, Houttuyniae herba 6 g, Isatidis radix 1.5 g, Lonicerae flos 0.6 g, Scutellariae radix 1.5 g) first gained prominence during the 2002 SARS epidemic. With no Western medicine available, the following overview discusses efficacy and mechanisms in view of viral entry and replication of different East Asian herbal remedies for COVID-19 treatment.

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“…SFJDC is mainly used to treat fever, parotitis, amygdalitis, plague, and other diseases (48). Recent studies have shown that SFJDC has been widely used in the clinical treatment of viral diseases, such as Middle East Respiratory Syndrome (MERS), influenza, human infection with H7N9 avian influenza, and respiratory diseases (such as acute upper respiratory illness, acute exacerbation of chronic obstructive pulmonary disease, and pneumonia) (7). Based on clinical data, SFJDC might be a promising candidate for the treatment of COVID-19.…”

Section: Clinical Efficacy Of Sfjdcmentioning

confidence: 99%

“…Traditional Chinese medicine (TCM) has been used for thousands of years in China to treat human diseases. Shufeng Jiedu capsule (SFJDC), a TCM containing eight types of herbal medicines, has a history of more than 30 years as a treatment for acute lung injury (ALI) and respiratory infections in China (7). SFJDC has been recommended by the China Food and Drug Administration (CFDA) for the treatment of the 2009 influenza A (H1N1)-related upper respiratory tract infections since 2009.…”

Section: Introductionmentioning

confidence: 99%

Potential therapeutic effect of Shufeng Jiedu capsule and its major herbs on coronavirus disease 2019 (COVID-19): A review

Wang

et al. 2021

DD&T

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Shufeng Jiedu capsule, coronavirus disease 2019, chemical composition, pharmacological properties, antiviral, anti-inflammatoryThe outbreak and rapid spread of coronavirus disease 2019 (COVID-19) poses a huge threat to human health and social stability. Shufeng Jiedu capsule (SFJDC), a patented herbal drug composed of eight medicinal plants, is used to treat different viral respiratory tract infectious diseases. Based on its antiviral, anti-inflammatory, and immunoregulatory activities in acute lung injury, SFJDC can be effectively used as a treatment for COVID-19 patients according to the diagnosis and treatment plan issued in China and existing clinical data. SFJDC has been recommended in 15 therapeutic regimens for COVID-19 in China. This review summarizes current data on the ingredients, chemical composition, pharmacological properties, clinical efficacy, and potential therapeutic effect of SFJDC on COVID-19, to provide a theoretical basis for its anti-viral mechanism and the clinical treatment of COVID-19.

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Systematic analyses on the potential immune and anti-inflammatory mechanisms of Shufeng Jiedu Capsule against Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2)-caused pneumonia

Abstract: Graphical abstract

Cited by 22 publications

References 49 publications

Traditional Chinese medicine in COVID-19

Traditional Chinese medicine in COVID-19

Which East Asian herbal medicines can decrease viral infections?

Potential therapeutic effect of Shufeng Jiedu capsule and its major herbs on coronavirus disease 2019 (COVID-19): A review

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