Systematic age‐, organ‐, and diet‐associated ionome remodeling and the development of ionomic aging clocks

Zhang, Bohan; Podolskiy, Dmitriy I.; Mariotti, Marco; Seravalli, Javier; Gladyshev, Vadim N.

doi:10.1111/acel.13119

Cited by 15 publications

(15 citation statements)

References 27 publications

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“…Principal Component Analysis (PCA) shows organ-specific metallomic and isotopic signatures (Fig. 1b ) as described before 12 – 14 . The first principal component is driven oppositely by protein-bound transition metals (Fe, Zn, Se, Mn, Co, and Cu) and free alkali and alkaline earth metals (Ca, K, and Mg) (Fig.…”

Section: Resultsmentioning

confidence: 97%

The mouse metallomic landscape of aging and metabolism

et al. 2022

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Organic elements make up 99% of an organism but without the remaining inorganic bioessential elements, termed the metallome, no life could be possible. The metallome is involved in all aspects of life, including charge balance and electrolytic activity, structure and conformation, signaling, acid-base buffering, electron and chemical group transfer, redox catalysis energy storage and biomineralization. Here, we report the evolution with age of the metallome and copper and zinc isotope compositions in five mouse organs. The aging metallome shows a conserved and reproducible fingerprint. By analyzing the metallome in tandem with the phenome, metabolome and proteome, we show networks of interactions that are organ-specific, age-dependent, isotopically-typified and that are associated with a wealth of clinical and molecular traits. We report that the copper isotope composition in liver is age-dependent, extending the existence of aging isotopic clocks beyond bulk organic elements. Furthermore, iron concentration and copper isotope composition relate to predictors of metabolic health, such as body fat percentage and maximum running capacity at the physiological level, and adipogenesis and OXPHOS at the biochemical level. Our results shed light on the metallome as an overlooked omic layer and open perspectives for potentially modulating cellular processes using careful and selective metallome manipulation.

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Section: Resultsmentioning

confidence: 97%

The mouse metallomic landscape of aging and metabolism

et al. 2022

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“…Animal experiments revealed that zinc affects the extracellular matrix of the vagina. Also, in aging mice and rats, the tissue concentration of zinc and copper decreases [13][14][15]. Histological and histochemical pictures of vaginas from mice with a zinc-deficient diet look similar to ovariectomized animals.…”

Section: Introductionmentioning

confidence: 85%

“…Tissue levels of zinc and copper decrease with aging in animals [13][14][15], but previously no data has been available regarding animal or human vaginal tissues. However, in the human uterus (corpus) during menopause, copper levels were seen to rise as zinc levels fell [23].…”

Section: Discussionmentioning

confidence: 99%

Evaluation of zinc and copper levels in vaginal tissues and whole blood: correlation with age

Csikós¹,

Kozma

Baranyai

et al. 2021

BMC Women's Health

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Background Zinc and copper are essential trace elements and play a crucial role in the homeostasis of connective tissues. In this study, we aimed to define zinc and copper levels in the vaginal tissue and establish whether a correlation exists between the zinc and copper levels either or both in whole blood or vaginal tissue samples and whether the finding correlates with the age of the patient or at least with her menopausal status. Methods We collected whole blood and vaginal tissue samples from 32 women and measured their zinc and copper levels by inductively coupled plasma optical emission spectrometry. We have performed Student's t test to evaluate the differences in the mean levels of trace elements and multiple regression to evaluate the association between vaginal tissue zinc/copper levels and age, menopausal status, number of vaginal deliveries, and zinc/copper blood levels. Results Zinc levels were significantly higher in both the vaginal tissues and whole blood samples than copper levels (p < 0.01). In the vaginal tissue samples, a strong positive correlation could be detected between zinc and copper levels (r = 0.82, p < 0.01). In the vaginal tissue, a negative correlation was found for zinc and copper levels with the age of women (r = − 0.27, p = 0.04 and r = − 0.56, p < 0.01). Multiple linear regression model (age, menopausal status, vaginal delivery and copper/zinc blood levels) showed that only age remained a significant predictor for zinc and copper vaginal tissues levels (p = 0.03, 95% CI − 2.28 to − 0.06; p = 0.004, 95% CI − 1.76 to − 0.34). Conclusions Zinc and copper levels in the vaginal tissue decline with age. Out of the examined variables (age, menopausal status, vaginal delivery, and copper/zinc levels), only age is a significant predictor of vaginal zinc/copper levels.

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“…ICP-MS has the ability to detect not only many metals and non-metals at very low concentration (such as part per trillion) but also different isotopes of the same element, whereas ICP-OES offers the advantages of lower cost and simplicity of acquisition and operation [ 34 , 35 ]. In recent years, both ICP-MS and ICP-OES have been successfully used for large-scale ionomic studies in yeast, plants, and animals, which demonstrate the power of ionomics to investigate new aspects of trace element metabolism and status [ 15 , 17 , 18 , 36 , 37 , 38 , 39 , 40 ].…”

Section: An Overview Of Ionomics and Its Application In Mammalsmentioning

confidence: 99%

“…Very recently, the ionomic profiles of eight organs throughout the lifespan of mice were quantified, which showed new interactions between elements at different levels [ 40 ]. The organ ionomes were stable throughout the entire lifespan, and aging was generally characterized by the reduced levels of elements and their increased variance.…”

Section: An Overview Of Ionomics and Its Application In Mammalsmentioning

confidence: 99%

Disease Ionomics: Understanding the Role of Ions in Complex Disease

Zhang

Zheng

2020

IJMS

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Ionomics is a novel multidisciplinary field that uses advanced techniques to investigate the composition and distribution of all minerals and trace elements in a living organism and their variations under diverse physiological and pathological conditions. It involves both high-throughput elemental profiling technologies and bioinformatic methods, providing opportunities to study the molecular mechanism underlying the metabolism, homeostasis, and cross-talk of these elements. While much effort has been made in exploring the ionomic traits relating to plant physiology and nutrition, the use of ionomics in the research of serious diseases is still in progress. In recent years, a number of ionomic studies have been carried out for a variety of complex diseases, which offer theoretical and practical insights into the etiology, early diagnosis, prognosis, and therapy of them. This review aims to give an overview of recent applications of ionomics in the study of complex diseases and discuss the latest advances and future trends in this area. Overall, disease ionomics may provide substantial information for systematic understanding of the properties of the elements and the dynamic network of elements involved in the onset and development of diseases.

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Systematic age‐, organ‐, and diet‐associated ionome remodeling and the development of ionomic aging clocks

Cited by 15 publications

References 27 publications

The mouse metallomic landscape of aging and metabolism

The mouse metallomic landscape of aging and metabolism

Evaluation of zinc and copper levels in vaginal tissues and whole blood: correlation with age

Disease Ionomics: Understanding the Role of Ions in Complex Disease

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