System dynamics and bio‐medical modeling

Karanfil, Özge; Hosseinichimeh, Niyousha; Duggan, Jim

doi:10.1002/sdr.1675

Cited by 2 publications

(2 citation statements)

References 37 publications

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“…The application of system dynamics to issues in biomedicine is a truly new and exciting domain that could yield additional unimagined results (see also Karanfil et al ., 2020, and notably, İrsoy et al . 2020 among additional research papers in that special issue of the SDR).…”

Section: Conclusion and A Few Ways Forwardmentioning

confidence: 94%

“…The application of system dynamics to issues in biomedicine is a truly new and exciting domain that could yield additional unimagined results (see also Karanfil et al, 2020, andnotably, _ Irsoy et al 2020 among additional research papers in that special issue of the SDR). Repeated here is a challenge from Dr. Jim McCarthy, former chair of Mayo Clinic's Department of Hypertension and Nephrology, a true champion for this project:…”

Section: Conclusion and A Few Ways Forwardmentioning

confidence: 99%

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Agency in physiological dynamics

Rogers¹,

Gallaher

Dingli

2022

System Dynamics Review

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With a view to finding new applications of biomedical system dynamics, this article expands upon on our talk at the 2021 International System Dynamics Conference on the occasion of receiving the J. W. Forrester Award for the article, "Personalized ESA doses for anemia management in hemodialysis patients with end-stage renal disease" (System Dynamics Review 2018, 34(1-2): 121-153). We summarize the evolution of a project which took place in a clinical setting between 2008 and 2015 that led to the award-winning article. We present concepts from receptor theory that informed the first system dynamics application of biophysical system dynamics to the successful diagnosis, prescription, administration, and improvement of individualized patient care. We expand upon these ideas to present a generalized structure, DART (Dynamic Approach to Receptor Theory). It can be used to simulate the physiological effects of any agent, be it an exogenous pharmacological agent, an endogenous enzyme or hormone, or a toxin of some sort. We suggest including within the pharmacological technical literature easily acquired but frequently omitted critical parameter values and rate constants. These would enable researchers to perform transient analyses of biophysical phenomena in addition to static equilibrium analyses typically performed. With the availability of this data, we suggest that the fundamental tools of system dynamics might be used to reconceptualize the 100-year-old field of "occupation theory" (today, receptor theory) to deliver high-resolution insights into physiological dynamics and the preventive, prescriptive, and palliative interventions they might require. It is our hope that these ideas could pave the way forward to novel, groundbreaking applications in biomedical system dynamics.

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Section: Conclusion and A Few Ways Forwardmentioning

confidence: 94%

Section: Conclusion and A Few Ways Forwardmentioning

confidence: 99%

Agency in physiological dynamics

Rogers¹,

Gallaher

Dingli

2022

System Dynamics Review

View full text Add to dashboard Cite

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Measuring the impact of donations at the Bottom of the Pyramid (BoP) amid the COVID-19 pandemic

et al. 2022

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The governments' isolation measures to contain the transmission of COVID-19 imposed a dilemma for the people at the bottom of the pyramid. Since these people have very unreliable sources of income, a dilemma arises: they must either work under risky conditions or refrain from work and suffer from income cuts. Emergency donations of food and cleaning supplies in a pandemic context might be overlooked by government and civil society actors. This paper aims to model the effects of donations on mitigating the negative effects of COVID-19 on vulnerable communities. Applying the system dynamics method, we simulated the behaviour of the pandemic in Rio de Janeiro (Brazil) communities and the impacts that donations of food and cleaning supplies have in these settings. We administered surveys to the beneficiaries and local organisations responsible for the final distribution of donations to gather information from the field operations. The results show that increasing access to cleaning supplies in communities through donations can significantly reduce coronavirus transmission, particularly in high-density and low-resource areas, such as slums in urban settings. In addition, we also show that food donations can increase the vulnerable population’s ability to afford necessities, alleviating the stress caused by the pandemic on this portion of the population. Therefore, this work helps decision-makers (such as government and non-governmental organisations) understand the impacts of donations on controlling outbreaks, especially under COVID-19 conditions, in a low-resource environment and, thus, aid these hard-to-reach populations in a pandemic setting.

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System dynamics and bio‐medical modeling

Cited by 2 publications

References 37 publications

Agency in physiological dynamics

Agency in physiological dynamics

Measuring the impact of donations at the Bottom of the Pyramid (BoP) amid the COVID-19 pandemic

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