Syringocystadenoma Papilliferum: A Case Report and Review of the Literature

Hawsawi, Khalid Al; Alharazi, Amani; Ashary, Abeer; Siddique, Asmaa

doi:10.1159/000497054

Cited by 5 publications

(7 citation statements)

References 4 publications

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“…2 The exact histogenesis of its origin remains debatable. 7 Features supporting its apocrine origin include epithelial lining composed of cells with prominent decapitation, staining of the luminal cells by Alcian blue, periodic acid-Schiff after diastase treatment, and colloidal iron methods. Positive immunohistochemical (IHC) staining for Gross Cystic Disease Fluid Protein 15, Leu-M1 antigen, and epithelial membrane antigen (EMA) also supports an apocrine origin.…”

Section: Discussionmentioning

confidence: 99%

Cytomorphological features of syringocystadenoma papilliferum mimicking pilomatricoma at a rare location and in an unusual age group: A cytological diagnostic challenge

Malik,

Singh,

Singh

et al. 2023

Diagnostic Cytopathology

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Syringocystadenoma papilliferum (SCAP) is a rare, benign skin adnexal tumor of apocrine or eccrine differentiation usually occurring in the head and neck region of children. It is a difficult entity to diagnose clinically and even cytological diagnosis remains challenging due to overlapping and masquerading cyto‐morphological features with other benign cutaneous adnexal tumors. Here we present, one such intriguing case of SCAP with its cytological features mimicking those of pilomatricoma. Moreover, the lesion was located at the right lower abdomen, which in itself is a rare site and its presentation was in an adult male which is an unusual age group. However, fine needle aspiration cytology still remains a very useful investigation for cutaneous tumors as it helps in differentiating benign lesions from malignant and metastatic neoplasms and therefore aids in correct treatment and follow‐up of patients.

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Section: Discussionmentioning

confidence: 99%

Cytomorphological features of syringocystadenoma papilliferum mimicking pilomatricoma at a rare location and in an unusual age group: A cytological diagnostic challenge

Malik,

Singh,

Singh

et al. 2023

Diagnostic Cytopathology

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“…Its clinical characteristics are non-specific with high variability of appearance and size ranging from a few millimeters to several centimeters [ 1 , 5 ]. The slowly growing fleshy plaque may sometimes ooze fluid or bleed [ 6 ]. There are three clinical types described: Plaque (located at scalp as an alopecic patch and may grow in size during puberty becoming nodular, verrucous or crusted), Solitary nodule (domed nodules 5–10 mm in size with peduncle, located at trunk, shoulder and axilla) and extremely rare type: Linear (multiple firm papule or umbilicated nodule 1–10 mm in size, pink-red in color, located at face and neck) [ 1 , 4 ].…”

Section: Discussionmentioning

confidence: 99%

“…Syringocystadenocarcinoma papilliferum—the malignant counterpart of syringocystadenoma papilliferum—is asymmetric, poorly circumscribed and often extending deep into the subcutaneous fat [ 8 ]. Histopathology shows many resemblances with the main differences being higher ratio of nuclear cytoplasmic, irregularity of nuclear, coarse chromatin and increased mitotic activity in syringocystadenocarcinoma papilliferum [ 6 ].…”

Section: Discussionmentioning

confidence: 99%

Syringocystadenoma papilliferum in a 20-year-old adult: a case report and literature review

Candrawinata

Koerniawan

Prasetiyo

et al. 2022

Journal of Surgical Case Reports

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Syringocystadenoma papilliferum is a rare, benign hamartomatous neoplasm of skin adnexal originating from pluripotent cells differentiating into either apocrine or eccrine sweat glands. It usually appears at birth, during infancy or puberty and commonly located at head and neck. This case report illustrates a rare occurrence at an atypical anatomical location and unusual onset. In this case report, we report a 20-year-old female with a chief complain of solitary pink-brown color fleshy plaque with soft-medium consistency on her left flank region since the last 7 months. She underwent complete surgical excision and histopathology examination, which confirmed the diagnosis as syringocystadenoma papilliferum without sign of malignancy, with main characteristics histologically include cystic invaginations from the epidermis lined by double layers of epithelial and myoepithelial cells. Despite having benign characteristics, rare transformations to malignancy have been reported. Therefore, complete surgical excision and histopathology examination should be done in suspicion of syringocystadenoma papilliferum.

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“…SCAP is a rare benign neoplasm of childhood classically[ 1 5 ] and some arising in later life as the patients in our case series. [ 6 ]…”

Section: Discussionmentioning

confidence: 99%

Unusual sites with variable presentation of de novo syringocystadenoma papilliferum: A case series

ASWAL

Hemdani

Johri

et al. 2022

J Family Med Prim Care

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Syringocystadenoma papilliferum (SCAP) is an uncommon, benign adnexal neoplasm that occurs de novo or in an organoid nevus. It usually presents as a skin-coloured to pink, solitary, smooth, hairless plaque, verruca or nodule frequently on the scalp and forehead. SCAP may be present at unusual sites including the arm, forearm, trunk and chest. Diagnosing SCAP arising on uncommon sites is difficult owing to its varied presentation. Mostly, they are wrongly diagnosed clinically and found to be SCAP only on histopathology. We present this study of cases of SCAP with unusual location and varied presentations, which were clinically misdiagnosed. The five cases included in this study were patients attending the dermatology outpatient department in a tertiary care centre in North India. The clinical presentation and the involved sites were noted by the dermatologist, and a clinical diagnosis was made. Biopsy of the lesions was sent for histopathological examination. There are five patients in the series – four are male and one female, with age ranging from 28 to 48 years. Locations included the forearm, arm, anterior chest wall and lateral abdominal wall. The lesions clinically appeared as warty papule or nodules and one lesion appeared within a plaque, with the average duration being 5.3 years. In all five patients, the lesions were clinically suspected to be either tuberculosis verruca cutis or nodular basal cell carcinoma or dermatofibroma sarcoma protuberans (DFSP) or verruca or fibroma or pyogenic granuloma. A confirmatory diagnosis of SCAP was made for all the patients on histopathology. We are presenting five cases which were misdiagnosed clinically due to the unusual location and varied presentation to emphasise the importance of histopathology in diagnosing SCAP arising de novo , which was clinically misdiagnosed. Also, we present this case series to alert the clinicians about the likelihood of SCAP on unusual locations with varied clinical presentation.

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Syringocystadenoma Papilliferum: A Case Report and Review of the Literature

Cited by 5 publications

References 4 publications

Cytomorphological features of syringocystadenoma papilliferum mimicking pilomatricoma at a rare location and in an unusual age group: A cytological diagnostic challenge

Cytomorphological features of syringocystadenoma papilliferum mimicking pilomatricoma at a rare location and in an unusual age group: A cytological diagnostic challenge

Syringocystadenoma papilliferum in a 20-year-old adult: a case report and literature review

Unusual sites with variable presentation of de novo syringocystadenoma papilliferum: A case series

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