Syringic acid exerts antiangiogenic activity by downregulation of VEGF in zebrafish embryos

Karthik, Gowri; Angappan, Mangalagowri; Vijayakumar, Arunkumar; Natarajapillai, Sukumaran

doi:10.1016/j.bionut.2014.01.007

Cited by 26 publications

(19 citation statements)

References 23 publications

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“…SRA is a major benzoic acid, derived from edible plants such as fruits and vegetables [ 14 ], and also used as a traditional Ayurvedic Indian medicine to treat diabetes. Several in vitro and in vivo investigations documented its beneficial role in various cancers and non communicable diseases [ 15 , 16 ].…”

Section: Introductionmentioning

confidence: 99%

“…Several in vitro and in vivo investigations documented its beneficial role in various cancers and non communicable diseases [ 15 , 16 ]. SRA has multiple pharmacological properties such as antioxidant, anti-lipid peroxidative, anti-inflammatory, immunomodulatory, anti-endotoxic, anti-mitogenic and anti-cancer effects [ [17] , [18] , [19] , [20] , [21] , 14 ]. SRA has potent anti-proliferative and hepatoprotective properties in human colorectal and breast cancer by scavenging their reactive oxygen species (ROS) [ 22 , 20 , 23 ].…”

Section: Introductionmentioning

confidence: 99%

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Syringic acid may attenuate the oral mucosal carcinogenesis via improving cell surface glycoconjugation and modifying cytokeratin expression

Velu

Vinothkumar

2018

Toxicology Reports

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Syringic acid may attenuate the oral mucosal carcinogenesis via improving cell surface glycoconjugation and modifying cytokeratin expression

Velu

Vinothkumar

2018

Toxicology Reports

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“…7 Karthik et al reported anti-angiogenic effects of SYRA in Zebra fish embryo at 20 to 50 µm range by down regulation of VEGF mRNA expression. 8 Tomak et al reported neuroprotective and antioxidant effects of SYRA on biochemical and histopathological parameters of spinal cord I/R injury in experimental rat models. 9 Anti-obesity, anti-inflammatory and anti-steatotic effects of SYRA were recently explored that suggests its utility in obesity or non-alcoholic liver disease.…”

Section: Introductionmentioning

confidence: 99%

Syringic Acid: Structural Elucidation and Co-Crystallization

Thipparaboina¹,

Mittapalli

Thatikonda³

et al. 2016

Crystal Growth & Design

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Syringic acid (SYRA) is a potential antioxidant used in traditional Chinese medicine and is an emerging nutraceutical. Current reports claim its potential anti-angiogenic, anti-glycating, antihyperglycaemic, neuroprotective, memory enhancing properties in various animal models. To date, SYRA crystal structure is not elucidated and no crystal engineering studies are reported.This study reports crystal structure of SYRA for the first time along with its nicotinamide (SNCT-E) and urea (SU-EA-M) cocrystals. All forms were successfully characterized using single crystal XRD, P-XRD and DSC. Single crystal analysis revealed that SYRA crystallized in C 2/c space group whereas SNCT-E (2:1) and SU-EA-M (1:2) crystallized in P 2 1 /n and Cmca space group respectively. Novel cocrystals have shown improved solubility, modified dissolution profiles, improved flow and compressibility. Cytotoxic effects were explored in DU145 prostate cancer cell lines for the first time and significant enhancement in cytotoxicity by the cocrystals was observed compared to plain components. Two folds increase in % cytotoxicity of SNCT-E was observed when compared to the corresponding physical mixture. These studies shed light on potential utility of SYRA as coformer for various pharmaceutical applications to design synergistic and organ protective cocrystals.

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“…Various biological activities of syringic acid like antiproliferative, anti-endotoxic, and anti-cancer activities have been reported. 21 Vanillic acid (10) is a flavoring agent found in edible plants and fruits. It has been previously reported to possess anti-nociceptive, antiinflammatory, and antibacterial activities.…”

Section: Resultsmentioning

confidence: 99%

Antioxidant Compounds Isolated from the Roots of Phlomis umbrosa Turcz.

Nguyen

Zhao

et al. 2018

Nat Prod Sci

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− Two triterpenoids, arjunolic acid (1), belleric acid (2), five phenylethanoids, martynoside (3), orobanchoside (4), 3,4-dihydroxyphenethylalcohol-6-O-caffeoyl-β-D-glucoside (5), leucosceptoside B (6), lunariifolioside (7), four phenolic acids, ferulic acid (8), syringic acid (9), vanillic acid (10), 4-hydroxybenzoic acid (11), and one lignan, (+)-syringaresinol-β-D-glucoside (12), were isolated from the roots of P. umbrosa. All isolated compounds were explored for their antioxidant potential in the DPPH and ABTS assays. In DPPH assay, compound 5 showed high antioxidant capacity. Compounds 3, 4, 6, and 7 displayed considerable antioxidant activities. In addition, compounds 5-7 exhibited potential antioxidant capacities in the ABTS assay.

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Syringic acid exerts antiangiogenic activity by downregulation of VEGF in zebrafish embryos

Cited by 26 publications

References 23 publications

Syringic acid may attenuate the oral mucosal carcinogenesis via improving cell surface glycoconjugation and modifying cytokeratin expression

Syringic acid may attenuate the oral mucosal carcinogenesis via improving cell surface glycoconjugation and modifying cytokeratin expression

Syringic Acid: Structural Elucidation and Co-Crystallization

Antioxidant Compounds Isolated from the Roots of Phlomis umbrosa Turcz.

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