Syringe Filling of High-Concentration mAb Formulation: Slow Suck-Back Pump Speed Prevented Filling Needle Clogging

Hanslip, Simon; Desai, Kashappa Goud H.; Palmer, Mark; Bell, Stephen A.; Schofield, Paul N.; Varma, Prashant; Roche, Frank; Colandene, James D.; Smith, Thomas M.; Nesta, Douglas P.

doi:10.1016/j.xphs.2017.08.005

Search citation statements

Order By: Relevance

Paper Sections

Select...

Filling1

Citation Types

Supporting

Mentioning

Contrasting

Year Published

2019

2022

Publication Types

Select...

Article5

Book1

Relationship

Self Cite1

Independent5

Authors

Journals

Cited by 13 publications

(1 citation statement)

References 3 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Additionally, for high protein concentration formulations, the suck-back (pump-reversal) on peristaltic pumps must be carefully controlled to avoid droplet formation on the end of the filling needle, which is prone to rapid drying and clogging of the filling needles during the process. 65,66 The time-pressure filling system is another technology that has gained increasing popularity in the pharmaceutical industry. One of the benefits of this system is reduced product contact parts and the absence of surface-to-surface contact (grinding) during the filling process.…”

Section: Fillingmentioning

confidence: 99%