Syringaresinol attenuates osteoarthritis via regulating the NF-κB pathway

Wang, Xianfeng; Wang, Dangrang; Deng, Biyong; Yan, Litao

doi:10.1016/j.intimp.2023.109982

Cited by 5 publications

(3 citation statements)

References 47 publications

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“…NF- κ B is a regulatory signal involved in the transcription of inflammatory cytokine genes and plays a central role in inflammation and general immune responses. Normally, almost all NF- κ B is cytoplasmically bound in an inactive form, inhibitor κB (IκB), but upon stimulation, IκB is rapidly degraded, and activated NF- κ B is released into the nucleus ( Leslie et al, 2000 ; Lawrence, 2009 ; Wang et al, 2023 ). It was tentatively suggested that the anti-inflammatory and analgesic activities of S. indicus branches and leaves were related to the NF- κ B pathway by measuring the expression levels of NF- κ B/p65, p -NF- κ B/p65, IkB α , and p -IkB α in ear tissues.…”

Section: Discussionmentioning

confidence: 99%

Anti-inflammatory and analgesic effects of Streblus indicus

Xie,

Huang,

Chen

et al. 2023

Front. Pharmacol.

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The bark of Streblus indicus, a Dai medicine in China, has been listed in the Chinese Materia Medica as possessing hemostatic and analgesic properties. Ethnic medicine books record that its bark or leaves for the treatment of mumps and lymphoma. However, according to the literature survey, anti-inflammatory and analgesic studies available for leaves and branches of S. indicus have been seldom reported so far. The current study focuses on the metabolites of S. indicus bark and leaves responsible for anti-inflammatory and analgesic effects on the basis of bioactive-included acetic acid writhing, hot-plate, and xylene-induced ear swelling. The secretion of inflammatory mediators, TNF-α, IL-6, IL-1β, IL-4, and IL-10, were evaluated for their anti-inflammatory by xylene-induced in mouse ear cells. Histological examination was used to assess the anti-inflammatory and analgesic effects of the branches and leaves of S. indicus, and Western blot analysis determined the mechanism of the methanolic extract of branches and leaves. Different metabolites of S. indicus significantly alleviated analgesic and anti-inflammatory effects, with no discernable differences among them. All metabolites decreased the levels of TNF-α, IL-1β, and IL-6 and increased the levels of IL-4 and IL-10. The analgesic and anti-inflammatory mechanism of the methanolic extract was related to the NF-kB signaling pathway. These results not only would account for scientific knowledge for the traditional application of S. indicus, but also provide a credible theoretical foundation for the further development of anti-inflammatory and analgesic agents.

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Section: Discussionmentioning

confidence: 99%

Anti-inflammatory and analgesic effects of Streblus indicus

Xie,

Huang,

Chen

et al. 2023

Front. Pharmacol.

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“…Moreover, TCM prescriptions Shengjie Tongyu decoction ( Wang et al, 2023 ), Zicui Tongmai decoction ( Wu et al, 2023 ), and Shenmai formula ( Li et al, 2023 ) have shown significant effects in alleviating DCM by a mechanism related to the regulation of the PI3K/AKT signaling pathway.…”

Section: Signaling Pathways In Tcm Intervening the Pathological Progr...mentioning

confidence: 99%

The signaling pathways of selected traditional Chinese medicine prescriptions and their metabolites in the treatment of diabetic cardiomyopathy: a review

Li,

Liu,

Liu

et al. 2024

Front. Pharmacol.

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Diabetic cardiomyopathy (DCM) is a myocardial-specific microvascular disease caused by diabetes that affects the structure and function of the heart and is considered to be the leading cause of morbidity and death in patients with diabetes. Currently, there is no specific treatment or preventive drug for DCM, and there is an urgent need to develop new drugs to treat DCM. Traditional Chinese medicine (TCM) has rich experience in the treatment of DCM, and its characteristics of multi-target, multi-pathway, multi-component, and few side effects can effectively deal with the complexity and long-term nature of DCM. Growing evidence suggests that myocardial fibrosis, inflammation, oxidative stress, apoptosis, cardiac hypertrophy, and advanced glycation end product deposition were the main pathologic mechanisms of DCM. According to the pathological mechanism of DCM, this study revealed the potential of metabolites and prescriptions in TCM against DCM from the perspective of signaling pathways. The results showed that TGF-β/Smad, NF-κB, PI3K/AKT, Nrf2, AMPK, NLRP3, and Wnt/β-catenin signaling pathways were the key signaling pathways for TCM treatment of DCM. The aim of this study was to summarize and update the signaling pathways for TCM treatment of DCM, to screen potential targets for drug candidates against DCM, and to provide new ideas and more experimental evidence for the clinical use of TCM treatment of DCM.

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“…In particular, IL-1β plays an essential role in OA progression by exacerbating inflammatory responses and the expression of over-induction-associated catabolic enzymes and inflammatory factors such as matrix metalloproteinases (MMPs), aggrecanases, cyclooxygenase (COX)-2, inducible nitric oxide synthase (iNOS), prostaglandin E2 (PGE2), and a disintegrin and metalloproteinase with thrombospondin motifs (ADMATs). This leads to extracellular matrix (ECM) degradation in chondrocytes [6,7].…”

Section: Introductionmentioning

confidence: 99%

Analgesic, Anti-Inflammatory, and Chondroprotective Activities of Siraitia grosvenorii Residual Extract

Lee,

Kim

2024

IJMS

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Inflammation is crucial to osteoarthritis (OA) pathogenesis. The aim of this study was to evaluate Siraitia grosvenorii residue extract (NHGRE) obtained by extracting S. grosvenorii fruits with water as a potential food supplement for treating arthritis based on its analgesic, anti-inflammatory, and chondroprotective effects and the remaining residue with 70% ethanol. We observed the analgesic activity of NHGRE based on the acetic acid-induced writhing response in mice, examined its anti-inflammatory efficacy against carrageenan-induced paw oedema in mice, and investigated its effect on inflammatory cytokine expression in interleukin (IL)-1β-induced SW1353 cells. Furthermore, we determined its effects on cartilage protection in interleukin-1β (IL-1β)-treated SW1353 cells. NHGRE at 200 mg/kg significantly reduced the acetic acid-induced writhing response and prevented oedema formation in the carrageenan-induced paw oedema model. In IL-1β-induced SW1353 cells, NHGRE at 400 µg/mL reduced the expression of inflammation mediators such as tumour necrosis factor (TNF)-α (55.3%), IL-6 (35.4%), and prostaglandin E2 (PGE2) (36.9%) and down-regulated the expression of matrix metalloproteinase (MMP)-1 (38.6%), MMP-3 (29.3%), and MMP-13 (44.8%). Additionally, it restored degraded collagen II levels in chondrocytes. NHGRE plays a protective role in chondrocytes by regulating Nuclear factor kappa B (NF-κB) activation. Overall, NHGRE may be a useful therapeutic agent for OA by controlling pain, oedema formation, and inflammation-related mechanisms.

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Syringaresinol attenuates osteoarthritis via regulating the NF-κB pathway

Cited by 5 publications

References 47 publications

Anti-inflammatory and analgesic effects of Streblus indicus

Anti-inflammatory and analgesic effects of Streblus indicus

The signaling pathways of selected traditional Chinese medicine prescriptions and their metabolites in the treatment of diabetic cardiomyopathy: a review

Analgesic, Anti-Inflammatory, and Chondroprotective Activities of Siraitia grosvenorii Residual Extract

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