Syringa pinnatifolia Hemsl. fraction protects against myocardial ischemic injury by targeting the p53-mediated apoptosis pathway

Feng, Xiao; Zhang, Ruifei; Li, Junjun; Yuan, Chengfu; Zhao, Feng; Du, Xiaolang; Gao, Xiaoli; Cao, Lingfeng; Chen, Suyile; Tu, Pengfei; Chai, Xingyun

doi:10.1016/j.phymed.2018.09.188

Cited by 26 publications

(10 citation statements)

References 25 publications

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“…The present result showed that diosmetin treatment improved LVWT, LVEF, FS and HR, while reduced LVESV in neonatal rat with MI model. Feng et al 30 showed that the cardiac EF and FS of rats with myocardial ischaemia was significantly lower, which is consistent with our findings. Furthermore, HE staining showed that diosmetin treatment attenuated pathological damage from MI such as necrosis in heart tissue.…”

Section: Discussionsupporting

confidence: 93%

Diosmetin exerts cardioprotective effect on myocardial ischaemia injury in neonatal rats by decreasing oxidative stress and myocardial apoptosis

Zhang³

et al. 2020

Clin Exp Pharma Physio

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Myocardial injury caused by the myocardial ischaemia (MI) is still a troublesome condition in the clinic, including apoptosis, oxidative stress and inflammation. Diosmetin inhibits the cellular apoptosis and inflammatory response and enhances antioxidant activity. So, this study was designed to investigate the cardioprotective effects of diosmetin on MI model neonatal rats. Forty Sprague Dawley (SD) rats 7 days old were randomly divided into five groups. Four groups of rats received diosmetin (50, 100, and 200 mg/kg) or vehicle (MI group) after ischaemia. Another group received vehicle without ischaemia to serve as a control group. Rats were pretreated with diosmetin intraperitoneally for 7 days and intoxicated with isoproterenol (ISO, 85 mg/kg, sc) on the last 2 days. The expression of apoptotic molecules, myocardial systolic function index, antioxidant enzymes and myocardial enzyme was analyzed. Compared with the control group, the proliferation marker proteins of Ki67 were increased significantly (P < .05), the MI group significantly increased the cardiac apoptosis, oxidative stress and myocardial enzymes, and weakened myocardial contractility. The levels of p‐P65/P65 were increased significantly (P < .05) with decreased p‐AKT/AKT and p‐Nrf2/Nrf2 (P < .05). Nevertheless, pretreatment with diosmetin reversed these changes, especially high‐dose group. In summary, diosmetin has significant potential as a therapeutic intervention to ameliorate myocardial injury after MI and provides the rationale for further clinical studies.

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Section: Discussionsupporting

confidence: 93%

Diosmetin exerts cardioprotective effect on myocardial ischaemia injury in neonatal rats by decreasing oxidative stress and myocardial apoptosis

Zhang³

et al. 2020

Clin Exp Pharma Physio

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“…The peeled roots, stems, and twigs have long been used as a traditional Mongolian medicine in local for treating cardiovascular symptoms, asthma, pain, and fever [2] . Although listed as one of the third‐level national endangered plants in China, [3] SP is attracting attention from researchers because of its well‐known clinical efficiency in Inner Mongolia and anti‐acute myocardial infarction effect in modern research [4–9] …”

Section: Introductionmentioning

confidence: 99%

Syringenes M – Q, Eremophilane Sesquiterpenoid Dimers from the Peeled Stems ofSyringa pinnatifolia

Chai

et al. 2022

Chemistry & Biodiversity

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As a part of systematic studies on Syringa pinnatifolia, a continued phytochemical investigation guided by 1H‐NMR and LC/MS data on the ethanol extract afforded five new dimeric eremophilane sesquiterpenoids, namely syringenes M−Q (1–5). These structures were elucidated by extensive analysis of spectroscopic data, including infrared (IR), high‐resolution electrospray ionization mass spectrometry (HR‐ESI‐MS), nuclear magnetic resonance (NMR), quantum‐mechanics‐based computational analysis of NMR chemical shifts, and single‐crystal X‐ray diffraction. Compounds 4 and 5 showed inhibitory activities against NO production induced by lipopolysaccharide in RAW264.7 macrophage cells, with IC50 values of 5.1 and 9.3 μM, compared to positive control indomethacin (IC50 33.6 μM). These dimeric eremophilane sesquiterpenoids may be potential markers for discriminating this species from the genus Syringa and the Oleaceae family.

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“…Previous chemical studies demonstrated that SP is mainly constituted by lignans as major amount and a few content of sesquiterpenoids [4–7] . Pharmacological investigations demonstrated that SP volatile oil [8] or EtOH extract [9–11] showed anti‐acute myocardial ischemia (AMI) in vivo .…”

Section: Introductionmentioning

confidence: 99%

(+/−)‐Alashanoid N, Two Enantiomeric Sesquiterpenes from Syringa pinnatifolia

Huang

Jiao

et al. 2021

Chemistry & Biodiversity

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Two enantiomeric humulane sesquiterpenes, namely (+)‐alashanoid N (1a) and (−)‐alashanoid N (1b), along with two known analogs ((2R,3R,5R)‐2,3‐epoxy‐6,9‐humuladien‐5‐ol‐8‐one (2) and (2R,3S,5R)‐2,3‐epoxy‐6,9‐humuladien‐5‐ol‐8‐one (3)), were described from the peeled stems of a folk Mongolian herbal medicine Syringa pinnatifolia. Their structures were characterized based on UV, IR, NMR, and HR‐ESI‐MS data analyses, and the absolute configurations were determined by data analysis of X‐ray diffraction and quantum chemical calculations. (+/−)‐Alashanoid N showed inhibition against NO production in RAW 264.7 macrophage cells with IC50 values of 90.1 μM and 71.7 μM, and protective effect against oxygen‐glucose deprivation injury to H9c2 cells at a concentration of 20 μM and 5 μM, respectively.

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Syringa pinnatifolia Hemsl. fraction protects against myocardial ischemic injury by targeting the p53-mediated apoptosis pathway

Cited by 26 publications

References 25 publications

Diosmetin exerts cardioprotective effect on myocardial ischaemia injury in neonatal rats by decreasing oxidative stress and myocardial apoptosis

Diosmetin exerts cardioprotective effect on myocardial ischaemia injury in neonatal rats by decreasing oxidative stress and myocardial apoptosis

Syringenes M – Q, Eremophilane Sesquiterpenoid Dimers from the Peeled Stems ofSyringa pinnatifolia

(+/−)‐Alashanoid N, Two Enantiomeric Sesquiterpenes from Syringa pinnatifolia

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