Abstract:Purpose: This work presents a case of syphilitic outer retinopathy with findings similar to those of acute zonal occult outer retinopathy (AZOOR). We also discuss the clinical characteristics, treatment, and prognosis of this entity. Methods: A case report and systematic literature review are presented. Results: A 56-year-old woman presented with acute vision loss, localized photopsia, a central scotoma, and retinal findings that were all consistent with AZOOR. A further workup led to a diagnosis of syphilis. … Show more
Background and Objective:
Retrospective analysis correlating serologic titers of ocular syphilis with posterior segment manifestations.
Patients and Methods:
This study consisted of 40 patients (80 eyes imaged, 68 affected) with positive rapid plasma reagin (RPR) and
Treponema Pallidum
immunoglobulin G. We collected demographic and presentation data including HIV status, absolute CD4 count, RPR, cerebrospinal fluid-venereal disease research laboratory (CSF-VDRL) test, and retinal zone. We categorized imaging into syphilitic outer retinopathy (SOR), acute syphilitic posterior placoid chorioretinopathy, retinitis/chorioretinitis (RC), and papillitis. Multivariate analysis correlated HIV status, RPR, and VDRL titers with posterior segment findings and zone.
Results:
Mean age of 42.8 ± 10.7 years, with 70% male patients. Presenting visual acuity (logMAR) 0.66 ± 0.74 did not correlate with RPR, nor was it associated with papillitis, RC, or acute syphilitic posterior placoid chorioretinopathy. Higher RPR (≥ 1:128) positively associated with SOR (
P
= 0.031) and zone 1 (odds ratio [OR], 1.62;
P
= 0.02), but negatively associated with zone 2 (OR 0.35;
P
= 0.005). HIV positivity increased RC odds (OR, 4.45;
P
= 0.047).
Conclusion:
Higher RPR correlated with SOR and zone 1, whereas HIV positivity correlated with RC.
[
Ophthalmic Surg Lasers Imaging Retina
2024;55:XX–XX.]
Background and Objective:
Retrospective analysis correlating serologic titers of ocular syphilis with posterior segment manifestations.
Patients and Methods:
This study consisted of 40 patients (80 eyes imaged, 68 affected) with positive rapid plasma reagin (RPR) and
Treponema Pallidum
immunoglobulin G. We collected demographic and presentation data including HIV status, absolute CD4 count, RPR, cerebrospinal fluid-venereal disease research laboratory (CSF-VDRL) test, and retinal zone. We categorized imaging into syphilitic outer retinopathy (SOR), acute syphilitic posterior placoid chorioretinopathy, retinitis/chorioretinitis (RC), and papillitis. Multivariate analysis correlated HIV status, RPR, and VDRL titers with posterior segment findings and zone.
Results:
Mean age of 42.8 ± 10.7 years, with 70% male patients. Presenting visual acuity (logMAR) 0.66 ± 0.74 did not correlate with RPR, nor was it associated with papillitis, RC, or acute syphilitic posterior placoid chorioretinopathy. Higher RPR (≥ 1:128) positively associated with SOR (
P
= 0.031) and zone 1 (odds ratio [OR], 1.62;
P
= 0.02), but negatively associated with zone 2 (OR 0.35;
P
= 0.005). HIV positivity increased RC odds (OR, 4.45;
P
= 0.047).
Conclusion:
Higher RPR correlated with SOR and zone 1, whereas HIV positivity correlated with RC.
[
Ophthalmic Surg Lasers Imaging Retina
2024;55:XX–XX.]
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