Syphilitic cervical lymphadenopathy: return of an old foe

Bruce, Iain; Roper, Alexandra; Gayed, Sedki; Dąbrowski, Marcin; Morar, Pradeep

doi:10.1016/j.amjoto.2008.06.019

Cited by 9 publications

(13 citation statements)

References 9 publications

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“…In 5 (26%) cases, the oral lesions were multiples (Compilato et al , ; Lu and Eng, ; Junkins‐Hopkins, ; Mani, ), while in the other 14 (74%) cases, the most frequent site of onset of the disease was the tongue (five cases, 37%) (Ikenberg et al , ; Bruce et al , ; Aquilina et al , ; Oztürk et al , ), followed by the labial (three cases, 21%) (Rajlawat et al , ; Lu and Eng, ; Mani, ), the buccal mucosa (two cases, 14%) (Ibrahim and Malu, ; Lu and Eng, ), the palate (three cases, 21%) (Murrell, ; Lu and Eng, ; Ban et al , ), and the gingiva (1 case, 7%) (Ficarra et al ,).…”

Section: Resultsmentioning

confidence: 99%

“…The secondary lesions displayed a heterogeneous pattern: mucosal patches in 8 (42%) patients (Lu and Eng, 2002;Ozt€ urk et al, 1998;Ban et al, 1995;Mani, 1984), solitary or multiple ulcerations in 7 (37%) patients (Rajlawat et al, 2011;Ikenberg et al, 2010;Murrell, 2009;Bruce et al, 2009;Lu and Eng, 2002;Ficarra et al, 1993), a leukoplakia-like plaque in 2 (11%) cases (Compilato et al, 2009;Aquilina et al, 2003), aphthous lesions in 1 (5%) case (Ibrahim and Malu, 2009), and pseudomembranous lesions in 1 (5%) case (Junkins-Hopkins, 1996).…”

Section: Resultsmentioning

confidence: 99%

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Oral Syphilis: a retrospective analysis of 12 cases and a review of the literature

et al. 2013

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Oral Syphilis: a retrospective analysis of 12 cases and a review of the literature

et al. 2013

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“…Men who have sex with men, especially those infected with HIV, are the group with highest risk of infection [1][2][3][4]6] and where the highest frequency of extragenital location of primary syphilis has been observed [1,7].…”

Section: Discussionmentioning

confidence: 99%

“…This lesion starts as a papule and evolves into a painless ulcer, accompanied by enlarged, non-tender, regional lymph nodes. The chancre usually arises in external genitalia but can appear in other less common sites such as anus, rectum, perineum, oropharynx, lips and hands [1,7].…”

Section: Introductionmentioning

confidence: 99%

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Oropharyngeal Syphilis: Imaging and Pathologic Findings in Two Patients

Ripoll

Montironi

Alós

et al. 2016

Head and Neck Pathol

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Syphilis is a widespread infection with increasing frequency in developed countries, especially among men who have sex with men. We present two cases of oropharyngeal syphilis in two middle-aged men who presented with a painless tonsillar ulcer and progressive enlargement of cervical lymph nodes suspected of being a tonsillar tumour. A pathologic analysis of the ulcer led to an accurate diagnosis. We review the imaging and pathologic findings to emphasize the importance of taking syphilis into account in the differential diagnosis.

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Syphilitic lymphadenitis diagnosed via fine needle aspiration biopsy

Jang

Khan

Genden

et al. 2010

Diagnostic Cytopathology

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Syphilis is coming back in the recent a few decades especially in the gay and HIV populations. Since syphilis can be "the great mimic" clinically and pathologically, a case report with updated review can be helpful to the medical community. We report, a case of syphilitic lymphadenitis diagnosed via fine needle aspiration biopsy (FNAB). The pitfalls associated with the diagnosis of syphilitic lymphadenitis will be discussed. The patient's medical records were reviewed. The pertinent history, clinical course, and ancillary studies including FNAB cytology with special stains are presented. In addition to the case report, we discuss the diagnosis of syphilitic lymphadenitis and the role of FNAB cytology. This was a 37-year-old man presenting with a two-month history of a growing neck mass, night sweats, and a ten pound weight loss. The patient had been treated one month earlier for primary syphilis. Examination of the head and neck revealed a 3 cm right level II mass. FNAB cytology showed heterogeneous population of lymphocytes and plasma cells suggesting reactive changes. Modified silver staining of the cell block slide was performed and revealed spirochetes, consistent with syphilis. The patient's lymphadenitis resolved with a course of antibiotic treatment. Although lymphadenopathy is a rare presentation of syphilis, it should be included in the differential diagnosis for patients who offer a suspect history. FNAB with silver staining is an effective, minimally invasive way to confirm the diagnosis.

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Syphilitic cervical lymphadenopathy: return of an old foe

Cited by 9 publications

References 9 publications

Oral Syphilis: a retrospective analysis of 12 cases and a review of the literature

Oral Syphilis: a retrospective analysis of 12 cases and a review of the literature

Oropharyngeal Syphilis: Imaging and Pathologic Findings in Two Patients

Syphilitic lymphadenitis diagnosed via fine needle aspiration biopsy

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