Syphilis showing leukocytoclastic vasculitis

Kim, Dong Hyun; Choi, Se Rim; Lee, Kyung Real

doi:10.1111/j.1600-0560.2009.01347.x

Cited by 7 publications

(8 citation statements)

References 9 publications

(7 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Although its relationship with infectious diseases has previously been described 8 , LCV cases associated with syphilis and HIV coinfection are rare, and few clinical cases have been reported in medical literature 9 , 10 . Among these, we identified two reports related to HIV coinfection: a syphilitic roseola with histologic features of LCV 11 , and a description of LCV as the initial symptom of malignant syphilis in the setting of HIV 12 .…”

Section: Discussionmentioning

confidence: 99%

“…LCV is a histopathologic term that describes a form of vasculitis of small vessels which encompasses neutrophilic inflammatory infiltrate and degranulation, a process known as "leukocytoclasia" that can be related to multiple disease processes including autoimmune systemic vasculitides such as Anti-neutrophil Cytoplasmic Antibody (ANCA) associated vasculitis, Behçet's disease, and Cogan's syndrome; other autoimmune diseases include rheumatoid arthritis, systemic lupus erythematosus, Sjögren's syndrome, cryoglobulinemia and infection associated vasculitis related to viral (hepatitis B and C) and bacterial (especially endocarditis and meningococcemia) etiologies 5-7. Although its relationship with infectious diseases has previously been described 8 , LCV cases associated with syphilis and HIV coinfection are rare, and few clinical cases have been reported in medical literature 9,10 . Among these, we identified two reports related to HIV coinfection: a syphilitic roseola with histologic features of LCV 11 , and a description of LCV as the initial symptom of malignant syphilis in the setting of HIV 12 .…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Leukocytoclastic vasculitis in a patient with syphilis and HIV coinfection

Ordoñez

Sepulveda

Marín

et al. 2022

Rev. Inst. Med. trop. S. Paulo

View full text Add to dashboard Cite

Leukocytoclastic vasculitis (LCV) is a small vessel vasculitis characterized by an inflammatory infiltrate composed of neutrophils with fibrinoid necrosis and "leukocytoclasia", a term that refers to nuclei disintegration into fragments. LCV is related to multiple conditions including ANCA-associated vasculitis, cryoglobulinemia, IgA vasculitis, infectious and systemic diseases such as rheumatoid arthritis and systemic erythematous lupus (SLE) as well as infections and malignancy. We describe the clinical case of severe systemic vasculitis in a young male patient with secondary syphilis and HIV coinfection manifested by cutaneous and neurological involvement, as well as peripheral necrosis that requires bilateral lower limb amputation. The skin biopsy revealed histopathological changes compatible with endarteritis obliterans and LCV related to treponemal infection. This case highlights the plethora of clinical manifestations of treponemal infection and the diagnostic challenge this poses in current clinical practice.

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Leukocytoclastic vasculitis in a patient with syphilis and HIV coinfection

Ordoñez

Sepulveda

Marín

et al. 2022

Rev. Inst. Med. trop. S. Paulo

View full text Add to dashboard Cite

show abstract

“…It has already been reported in cases of syphilis; however, these are rare and are more commonly associated with types of skin lesion other than roseola. [10][11][12][13] Taytan et al reported a case of a 45-day old infant with a recent diagnosis of congenital syphilis, who presented with nephrotic syndrome and skin lesions (purplish papules and vesicular hemorrhages on the palms of the hands and soles of the feet), which histopathology revealed to be leukocytoclastic vasculitis. 10 Another recent publication by Chao et al reported the case of a 46 year old, HIV-negative male patient with multiple, painless ulcers on the glans penis.…”

Section: Discussionmentioning

confidence: 99%

Vasculite leucocitoclástica: mais uma "imitação" da sífilis

Furlan

Oliveira

Yoshioka

et al. 2010

An. Bras. Dermatol.

View full text Add to dashboard Cite

Syphilis, a disease that in the past was associated with significant morbidity and lethality rates, has resurged in recent years principally as a consequence of changes in risk behavior. An epidemiological group that is commonly affected is the HIV-infected population. The characteristics of the disease and its progression may differ in these patients. The present report describes a case of an HIV-positive male patient, who developed florid secondary syphilis: in addition to syphilitic roseola, he also presented with bilateral panuveitis and involvement of the central nervous system. Investigation revealed the prozone phenomenon and histological examination of the skin lesions showed the presence of leukocytoclastic vasculitis. This finding is extremely rare and few cases have been documented. Keywords: Histology; Syphilis; Syphilis serodiagnosis; HIV; Vasculitis Resumo: A sífilis, doença de importante morbiletalidade no passado, tem ressurgido nos últimos anos, graças, sobretudo, às alterações nos comportamentos de risco. Um grupo epidemiológico, frequentemente, acometido é a população com infecção pelo HIV: estes pacientes podem apresentar características peculiares nas manifestações e evolução da doença. Relatamos o caso de um paciente masculino, HIV-positivo, que desenvolveu um quadro florido de secundarismo: além da roséola sifilítica, apresentou pan-uveíte bilateral e acometimento do sistema nervoso central. A investigação, apresentou fenomeno pro-zona e no estudo histologico, mostrou a presenca de vasculite leucocitoclastica achado este extremamente raro e pouco documentado.

show abstract

“…Cardiovascular involvement reported later in the course of untreated syphilis, such as aortitis of ascending aorta, has been estimated to occur in 10% of untreated syphilis cases (68) . Retinal and cutaneous small-vessel vasculitis have also been reported (69) . Scrub typhus, a disease caused by mite-borne rickettsia, is an acute febrile disease caused by Orientia tsutsugamushi .…”

Section: Pathogen-associated Vasculitis In Humansmentioning

confidence: 99%

Pathogens in Vasculitis: Is It Really Idiopathic?

Miyabe

Miyata

et al. 2021

JMA J

View full text Add to dashboard Cite

Vasculitis is an autoimmune disease characterized by the infiltration of leukocytes in blood vessels. An increasing number of studies on human and animal models have implicated various microorganisms in the pathogenesis of vasculitis. Previous studies have shown the presence of infectious agents, including viruses, bacteria, and fungi, in diseased vessels. However, despite continued research, the link between infection and vasculitis is not fully understood, possibly owing to the lack of appropriate animal models that mirror human disease and the technical limitations of pathogen detection in blood vessels. Among the pathogen-induced animal models, Candida albicans water-soluble fraction (CAWS)-induced coronary arteritis is currently considered one of the representative models of Kawasaki (KD) disease. Advances in metagenomic next-generation sequencing have enabled the detection of all nucleic acids in tissue, which can help identify candidate pathogens, including previously unidentified viruses. In this review, we discuss the findings from reports on pathogen-associated vasculitis in animal models and humans, with a specific focus on the investigation of the pathogenesis of vasculitis. Further studies on animal models and microbes in diseased vessels may provide important insights into the pathogenesis of vasculitis, which is often considered an idiopathic disease.

show abstract

Syphilis showing leukocytoclastic vasculitis

Cited by 7 publications

References 9 publications

Leukocytoclastic vasculitis in a patient with syphilis and HIV coinfection

Leukocytoclastic vasculitis in a patient with syphilis and HIV coinfection

Vasculite leucocitoclástica: mais uma "imitação" da sífilis

Pathogens in Vasculitis: Is It Really Idiopathic?

Contact Info

Product

Resources

About