Syphilis screening and treatment in pregnant women in Kinshasa, Democratic Republic of the Congo and in Lusaka, Zambia: a cross-sectional study

Berrueta, Mabel; Ml, Cafferata; Mwenechanya, Musaku; D, Nkamba Mukadi; Althabe, Fernando; Bergel, Eduardo; Gibbons, Luz; Ciganda, Álvaro; Klein, Karen; A, Mwapule Tembo; F, Habulembe Mwanakalanga; Banda, Ernest; A, Mavila Kilonga; P, Lusamba Dikassa; Xiong, Xu; Chomba, Elwyn; Ak, Tshefu; Buekens, Pierre

doi:10.12688/gatesopenres.12768.1

Cited by 8 publications

(15 citation statements)

References 15 publications

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“…These health facilities that are designated as urban health centers with PMTCT programs in Lusaka District (91). During the baseline period, all women attending their first antenatal care visit at one of the 13 participating clinics during April 13, 2015 to January 10, 2016 were approached for study enrollment [24].…”

Section: Methodsmentioning

confidence: 99%

“…For enrolled participants, study personnel completed an antenatal care form at clinics [24]. Data was also collected from multiple source documents including antenatal care registry, antenatal card, PMTCT books, laboratory records, and nurses' books [24]. Unavailable data from the source documents were collected from the mothers [24].…”

Section: Methodsmentioning

confidence: 99%

“…Data was also collected from multiple source documents including antenatal care registry, antenatal card, PMTCT books, laboratory records, and nurses' books [24]. Unavailable data from the source documents were collected from the mothers [24]. During the baseline data period, the study team produced detailed weekly and monthly data monitoring reports.…”

Section: Methodsmentioning

confidence: 99%

“…This is a cross-sectional study focusing on 13 Lusaka district clinics participating in the nine month baseline period of Preventing Congenital Syphilis (PCS), a facility-based, two-arm parallel cluster randomized implementation trial (ClinicalTrials.gov: NCT02353117; registered on February 2, 2015) [ 23 ]. The objective of the PCS implementation trial was to evaluate a behavioral multifaceted intervention to increase the use of evidence-based clinical procedures to increase syphilis screening and treatment during antenatal care in antenatal clinics in Kinshasa, Democratic Republic of the Congo and Lusaka, Zambia [ 24 , 25 ].…”

Section: Main Textmentioning

confidence: 99%

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Factors associated with HIV and syphilis screenings among pregnant women at first antenatal visit in Lusaka, Zambia

et al. 2020

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Objectives To identify characteristics associated with obtaining HIV and syphilis screenings of pregnant women attending a first antenatal visit in Lusaka, Zambia. Results Among 18,231 participants from April 2015 to January 2016, 95% obtained HIV screening, 29% obtained syphilis screening, and 4% did not obtain antenatal HIV or syphilis screenings. Divorced/separated women were associated with a moderate decrease in prevalence of obtaining HIV (adjusted prevalence ratio (aPR) 0.88, 95% confidence interval (95% CI) 0.82, 0.95) and syphilis (aPR 0.51, 95% CI 0.27, 0.96) screenings compared to married women. Women with previous pregnancies were associated with a slight decrease in prevalence of obtaining HIV screening (aPR 0.97, 95% CI 0.95, 0.99) compared to women without previous pregnancy. Older women ≥ 35 years were associated with a slight decrease in prevalence of obtaining HIV screening (aPR 0.96, 95% CI 0.92, 0.99) compared to younger women. The statistically significant differences were not of clinical relevance as defined by a proportional difference of 10 percent. Findings of this study show that a vast majority of pregnant women are obtaining HIV screenings but not syphilis screenings during first antenatal visit. Provision of antenatal HIV and syphilis screening at first visit is only weakly related to patient level factors.

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Section: Methodsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Section: Main Textmentioning

confidence: 99%

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Factors associated with HIV and syphilis screenings among pregnant women at first antenatal visit in Lusaka, Zambia

et al. 2020

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“…Africa is the region with the greatest congenital syphilis burden is 63% of global maternal infections (585,664) and 64% of adverse pregnancy outcome (224,761). 5 The specificity of the test is being limited owing to the non-specific nature of the cardiolipin antigen as biological false positive reactions can occur due to viral infections, pregnancy and malaria. Although the false negative results may occur in early primary cases and in patients with secondary syphilis, as a result of prozone reactions this may limit the sensitivity of the test.…”

Section: Introductionmentioning

confidence: 99%

Seroprevalence of syphilis among pregnant females attending antenatal clinic at a tertiary care hospital in North India

et al. 2020

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Background: Syphilis is a sexually transmitted disease caused by bacteria named Treponema palladium, subsp. pallidum. Nearly 1.36 million pregnant women are known to be affected by syphilis in the developing countries. When left untreated syphilis during pregnancy can result in adverse fetal outcomes such as spontaneous abortion and stillbirth. Objective of the study was present study was done to evaluate the seroprevalence of syphilis among pregnant females attending Antenatal Clinic (ANC).Methods: A hospital based cross-sectional study was done over a period of six months from January to June 2019. A total of 132 pregnant females were included in the study who attended Antenatal Clinic for routine checkup whose blood samples were sent to Microbiology Laboratory for screening for syphilis by Rapid Plasma Reagin (RPR) test.Results: Out of 132 samples of pregnant females screened for syphilis, none of the sample was found reactive for syphilis by RPR test. Maximum patients (57.6%) belonged to age group 20-25 years followed by (27.3%) of 26-30 years. 30.3% patients belonged to urban areas and 69.7% patients belonged to rural areas. Majority of patients (80.3%) belonged to first trimester, followed by (18.9%) patients to second trimester and (0.8%) patients to third trimester. 78.8% patients were from lower socio-economic class followed by 12.9% patients from middle class and 8.3% patients from upper class.Conclusions: Although zero percent syphilis prevalence was observed in this study, it is recommended that free screening for syphilis should be offered to all pregnant females visiting Antenatal Clinic.

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A multifaceted intervention to improve syphilis screening and treatment in pregnant women in Kinshasa, Democratic Republic of the Congo and in Lusaka, Zambia: a cluster randomised controlled trial

Althabe

Chomba

Tshefu

et al. 2019

The Lancet Global Health

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Summary Background Despite international recommendations, coverage of syphilis testing in pregnant women and treatment of those found seropositive remains limited in sub-Saharan Africa. We assessed whether combining the provision of supplies with a behavioural intervention was more effective than providing supplies only, to improve syphilis screening and treatment during antenatal care. Methods In this 18-month, cluster randomised controlled trial, we randomly assigned (1:1) 26 urban antenatal care clinics in Kinshasa, Democratic Republic of the Congo, and Lusaka, Zambia, to receive a behavioural intervention (opinion leader selection, academic detailing visits, reminders, audits and feedback, and supportive supervision) plus supplies for syphilis testing and treatment (intervention group) or to receive supplies only (control group). The primary outcomes were proportion of pregnant women who had syphilis screening out of the total who attended the clinic; and the proportion of women who had treatment with benzathine benzylpenicillin out of those who tested positive for syphilis at their first antenatal care visit. This trial is registered at ClinicalTrials.gov , number NCT02353117 . Findings The 18-month study period was Feb 1, 2016, to July 14, 2017. 18 357 women were enrolled at the 13 intervention clinics and 17 679 women were enrolled at the 13 control clinics at their first antenatal care visit. Syphilis screening was done in a median of 99·9% (IQR 99·0–100·0) of women in the intervention clinics and 93·8% (85·0–98·9) in the control clinics (absolute difference 6·1% [95% CI 1·1–14·1]; p=0·00092). Syphilis treatment at the first visit was done in a median of 100% (IQR 99·7–100·0) of seropositive women in intervention clinics and 43·2% (2·6–83·2) of seropositive women in control clinics (absolute difference 56·8% [12·8–99·0]; p=0·0028). Interpretation A behavioural intervention, together with the provision of supplies, can lead to more than 95% of women being screened and treated for syphilis. The sole provision of supplies is sufficient to reach such levels of screening coverage but is not sufficient to ensure high levels of treatment. Funding Bill & Melinda Gates Foundation.

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Syphilis screening and treatment in pregnant women in Kinshasa, Democratic Republic of the Congo and in Lusaka, Zambia: a cross-sectional study

Cited by 8 publications

References 15 publications

Factors associated with HIV and syphilis screenings among pregnant women at first antenatal visit in Lusaka, Zambia

Factors associated with HIV and syphilis screenings among pregnant women at first antenatal visit in Lusaka, Zambia

Seroprevalence of syphilis among pregnant females attending antenatal clinic at a tertiary care hospital in North India

A multifaceted intervention to improve syphilis screening and treatment in pregnant women in Kinshasa, Democratic Republic of the Congo and in Lusaka, Zambia: a cluster randomised controlled trial

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