Syphilis in the United States: on the rise?

Peterman, Thomas A.; Su, John R.; Bernstein, Kyle T.; Weinstock, Hillard

doi:10.1586/14787210.2015.990384

Cited by 78 publications

(68 citation statements)

References 34 publications

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“…In Western countries, there has been a resurgence of syphilis since 2000 [1], with a peak prevalence in men who have sex with men (MSM) living with HIV [2, 3]. HIV infection has been associated with lower rates of serologically defined treatment responses, compared with the rates that have been observed in the general population [4, 5], although conflicting results on this topic have been reported [6, 7].…”

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confidence: 99%

Incidence and Predictors of Serological Treatment Response in Early and Late Syphilis Among People Living With HIV

Spagnuolo

Poli

Galli

et al. 2018

Open Forum Infectious Diseases

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BackgroundFew studies have investigated predictors of serological response to syphilis treatment in people living with HIV (PLWH).MethodsThis was a retrospective, longitudinal study on PLWH who were diagnosed with and treated for syphilis who had an assessable serological response between January 2004 and June 2016. Serological treatment response (TR) was defined as a ≥4-fold decline in rapid plasma reagin (RPR) titers or a reversion to nonreactive (if RPR ≤1:4 at diagnosis) 12 months after treatment for early syphilis and 24 months after treatment for late syphilis. Factors associated with a TR were assessed with multivariate Cox proportional hazard models for recurrent events.ResultsA total of 829 episodes of syphilis (686 early, 143 late) in 564 patients were recorded. TR was observed in 732 (88%) syphilis episodes. The proportion of TR differed between early and late syphilis (89% vs 83%, respectively; P = .045). For early syphilis, TR was associated with a higher nadir CD4+ cell count (adjusted hazard ratio [AHR], 1.06; P = .029), an RPR titer >1:32 at diagnosis (AHR, 1.26; P = .009), secondary syphilis (AHR, 1.29; P = .008), and cases of syphilis diagnosed in more recent calendar years (AHR, 1.36; P < .0001). In late syphilis, TR was more likely to occur for first infections (AHR, 1.80; P = .027), for episodes that occurred in more recent years (AHR, 1.62; P = .007), and for RPR titers >1:32 at diagnosis (AHR, 2.04; P = .002). TR was not associated with the type of treatment regimen in early and late syphilis.ConclusionsHigher RPR titers at diagnosis and a diagnosis of syphilis that was made in more recent years were associated with TR in early and late syphilis.

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confidence: 99%

Incidence and Predictors of Serological Treatment Response in Early and Late Syphilis Among People Living With HIV

Spagnuolo

Poli

Galli

et al. 2018

Open Forum Infectious Diseases

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“…1 Syphilis has been generally eradicated, however, it still remains in the developing world and is increasing in developed countries. 2,3 The World Health Organization (WHO) has estimated that nearly one million pregnant women worldwide are infected with syphilis annually. 4 The number of reported congenital syphilis has increased in Korea after the sentinel surveillance system started in 2001.…”

Section: Introductionmentioning

confidence: 99%

Outcome of infants born to pregnant women with syphilis: A nationwide study in Korea

Lim

Yoon

Shin

et al. 2020

Preprint

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BackgroundAlthough expansion of antenatal syphilis screening programs, congenital syphilis (CS) is still remaining issue. This study aimed to analyze the manifestation and progress of CS including treatment and follow-up based on nationwide study.MethodsFrom the Korean National Health Insurance Service database, a total of 548 infants were examined for CS during first year of life from 2013 to 2018. Neurosyphilis and complications were investigated using International Classification of Diseases-10 codes.ResultsThe birth rate from mother with syphilis was 2.8 per 10,000 live birth for 5 years, not showing tendency to decrease. One hundred forty-eight infants were proven or highly probable or possible for CS with treatment over 10 days. Sixty-six infants were possible or less likely CS with only 1-day treatment. Jaundice (56%) was most common and hearing impairment (14%), renal disease (8%), mental retardation (8%) followed. Total of 14 cases of neurosyphilis occurred. Patients who have complications such as mental retardation, eye involvement, hearing impairment and renal disease were significantly associated with neurosyphilis (OR 8.49, P < 0.0001). Among 250 patients with treatment, 92.8% was treated with 1 medication; Benzathine penicillin G was more used (72.4%) than aqueous crystalline penicillin G. Only 4 patients were retreated due to treatment failure. In addition to the treponemal test, fluorescent treponemal antibody-absorption was the most prescribed tool of diagnosis for follow up.ConclusionSharing a standardized guideline for evaluation and treatment regimens and follow up plan at a national level is needed for maternal neonatal care leading to eradication of CS.

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“…12 . Nos Estados Unidos, o número de casos, a mortalidade e a morbidade por SC estão diminuindo anualmente 13,14 .…”

Section: Introductionunclassified

Sífilis congênita: características epidemiológicas do binômio mãe/filho atendidos em um hospital público de ensino

Nasciutti

Vasconcelos

Rocha³

et al. 2019

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O presente estudo teve como objetivo identificar os casos de Sífilis Congênita e caracterizar as mães e os recém-nascidos no período de janeiro de 2010 a dezembro de 2015, realizado em 2016. Estudo descritivo, retrospectivo, com dados do Núcleo de Vigilância Epidemiológica do Hospital de Clínicas da Universidade Federal do Triângulo Mineiro de Uberaba-MG. Identificou-se 70 casos de sífilis congênita. As mães com idade entre 20 a 29 anos (51,3%), com baixa escolaridade (48,6%), solteiras (48,6%), diagnosticadas no pré-natal (70%), sendo o tratamento inadequado ou inexistente (80%). Os recém-nascidos eram do sexo masculino (54,3%), com idade gestacional média de 37 semanas, eram sintomáticos (51,4%), foram tratados (97,3%) e receberam alta hospitalar (95,4%). O número de casos elevou-se de 5,7% em 2010 para 58,6% em 2014. Os achados desse estudo são relevantes à medida que evidencia um aumento significante de casos de sífilis congênita, alta taxa de tratamento inadequado das gestantes e não adesão do parceiro ao mesmo, em especial por déficit na atenção primária à saúde.

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Syphilis in the United States: on the rise?

Cited by 78 publications

References 34 publications

Incidence and Predictors of Serological Treatment Response in Early and Late Syphilis Among People Living With HIV

Incidence and Predictors of Serological Treatment Response in Early and Late Syphilis Among People Living With HIV

Outcome of infants born to pregnant women with syphilis: A nationwide study in Korea

Sífilis congênita: características epidemiológicas do binômio mãe/filho atendidos em um hospital público de ensino

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