Syphilis in Poland is on the rise and underreported

Teter, Zbigniew; Majkut, Gabriela; Wierzba, Waldemar; Śliwczyński, Andrzej; Brzozowska, Melania; Jacyna, Andrzej; Marczak, Michał; Myśliwiec, M

doi:10.5114/ada.2019.84595

Cited by 5 publications

(4 citation statements)

References 4 publications

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“…In 2017, 1710 persons were infected with syphilis in Poland (Biuletyn Statystyczny Ministerstwa Zdrowia 2018). According to Teter et al (2019), these results are severely underestimated. His study shows that in the years 2010-2016, the number of syphilis cases in Poland according to NFZ (National Healthcare Fund) data was twice higher than what is indicated by the statistics of the obligatory system of epidemiological surveillance.…”

Section: Resultsmentioning

confidence: 99%

Using Joinpoint Regression for the Analysis of Trends in Syphilis Incidence in Poland in the Years 1950–2017

Milewski

Sokołowska

et al. 2019

Studies in Logic, Grammar and Rhetoric

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Syphilis is a bacterial sexually transmitted disease (STD), whose main route of infection is through sexual contact. In order to diagnose syphilis, Treponema pallidum must be detected in the material sampled from a lesion and a blood test must be performed in order to detect serological response to syphilis. Since 1946, a statutory obligation to report all cases of syphilis has been in force in Poland, which is why data concerning the incidence is available. The aim of this paper is to analyse trends in syphilis incidence in the years 1950–2017 using Joinpoint Regression and to present the impact of prophylaxis and education of society on syphilis prevention. The Joinpoint Regression method indicated the splitting time points of the trend corresponding to real changes in incidence, which corroborates the purpose of using the method in question in epidemiological studies.

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Section: Resultsmentioning

confidence: 99%

Using Joinpoint Regression for the Analysis of Trends in Syphilis Incidence in Poland in the Years 1950–2017

Milewski

Sokołowska

et al. 2019

Studies in Logic, Grammar and Rhetoric

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“…A study carried out in Poland reports that despite the availability of diagnostic tests and effective treatment, problems with surveillance and reporting of this infectious disease occur. Although notification to the epidemiological surveillance system is mandatory, health professionals' low awareness generates underreporting (Teter et al, 2019).…”

Section: Discussionmentioning

confidence: 99%

Consumption of benzylpenicillin as a syphilis control indicator

Silva

Bueno

Pilger

2023

Braz. J. Pharm. Sci.

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Syphilis is a disease with compulsory and mandatory notification to the Notifiable Diseases Information System (SINAN), with benzathine benzylpenicillin being the treatment of choice. The aim of the study was to compare the consumption of benzylpenicillin benzathine, from the dispensation, between the health regions of a capital in the southern region of the country, according to the georeferencing of notified cases of syphilis. This is a descriptive, crosssectional, retrospective study of the use of benzylpenicillin benzathine and of reported cases of syphilis. Data on syphilis cases were obtained from notifications made in SINAN, and drug consumption data were obtained from the Municipal Health Department computerized system for Drug Dispensing from January 1 st , 2019 to December 31 st , 2019. Notifications and drug consumption were georeferenced according to 8 health regions. From the compilation of data, the rates of cases and consumption in relation to the population of each region were calculated. A total of 3188 notifications and a total of 35191 vials of benzathine benzylpenicillin were analyzed. The ratio of vials by SINAN notifications showed that each patient took 11 vials of the drug, which is a higher value if we consider that the complete treatment is 2 to 6 vials per case.

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“…Syphilis is a sexually transmitted infection caused by Treponema pallidum (Chiquet et al, 2014). Epidemiological data indicate an increasing annual prevalence of syphilis, with the highest incidence among sexually transmitted diseases (STDs) (da Motta et al, 2018; Futami et al, 2019; Teter et al, 2019). Previous research has shown that T. pallidum possesses the ability to evade the host immune defenses, resulting in prolonged and persistent infections with serious clinical consequences (Li et al, 2013; Qin et al, 2015; Spagnuolo et al, 2019).…”

Section: Introductionmentioning

confidence: 99%

The outer membrane protein Tp92 of Treponema pallidum delays human neutrophil apoptosis via the ERK, PI3K/Akt, and NF‐κB pathways

Li,

Wang

et al. 2023

Molecular Microbiology

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Syphilis is a persistent sexually transmitted disease caused by infiltration of the elusive pathogen Treponema pallidum. Despite the prevalence of human polymorphonuclear neutrophils (hPMNs) within cutaneous lesions, which are characteristic of incipient syphilis, their role in T. pallidum infection remains unclear. Tp92 is the only T. pallidum helical outer membrane protein that exhibits structural features similar to those of outer membrane proteins in other gram‐negative bacteria. However, the functional mechanism of this protein in immune cells remains unclear. Neutrophils are short‐lived cells that undergo innate apoptosis in response to external stimuli that typically influence this process. In this study, we determined that Tp92 impedes the activation of procaspase‐3 via the ERK MAPK, PI3K/Akt, and NF‐κB signaling pathways, consequently suppressing caspase‐3 activity within hPMNs, and thereby preventing hPMNs apoptosis. Furthermore, Tp92 could also modulate hPMNs apoptosis by enhancing the expression of the anti‐apoptotic protein Mcl‐1, stimulating IL‐8 secretion, and preserving the mitochondrial membrane potential. These findings provide valuable insights into the molecular mechanisms underlying T. pallidum infection and suggest potential therapeutic targets for syphilis treatment.

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Syphilis in Poland is on the rise and underreported

Cited by 5 publications

References 4 publications

Using Joinpoint Regression for the Analysis of Trends in Syphilis Incidence in Poland in the Years 1950–2017

Using Joinpoint Regression for the Analysis of Trends in Syphilis Incidence in Poland in the Years 1950–2017

Consumption of benzylpenicillin as a syphilis control indicator

The outer membrane protein Tp92 of Treponema pallidum delays human neutrophil apoptosis via the ERK, PI3K/Akt, and NF‐κB pathways

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