Syphilis and Human Immunodeficiency Virus Co-infection among Pregnant Women in Nigeria: Prevalence and Trend

Omisakin, C. T.; Esan, A. J.; Fasakin, K. A.; Owoseni, M. F.; Ojo-Bola, O.; Aina, O. O.; Omoniyi, D. P.

doi:10.9734/isrr/2014/10946

Cited by 5 publications

(4 citation statements)

References 16 publications

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“…HIV-syphilis co-infection, 0.9% in the present study is in harmony with a study conducted in Gondar, 1% [43] but higher than 0.3% in Tanzania [50] but lower than 2.2% reported in north Ethiopia [9]. In the contrary to this, our finding was higher than, 0.05% reported in Nigeria [53].…”

Section: Discussionsupporting

confidence: 84%

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Sero-Prevalence of HIV and Syphilis Infection Among Pregnant Mothers Attended Labor Ward at Wolaita Sodo University Teaching Referral Hospital: A Five-Year Retrospective Study (2012-2016)

Ageru¹

2018

AJHR

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Sexually transmitted infections (STIs) such as HIV and Syphilis infections are the major public health problem in the developing countries. The prevalence of syphilis and HIV infections among pregnant women has been shown to vary by geographic areas, study population and time-period. Objective: The aim of study was to assess sero prevalence of HIV and syphilis and associated factors among pregnant women attended labor ward at Wolaita Sodo University Teaching and Referral Hospital. Method: Retrospective study was conducted using standard extraction format to assess the sero-prevalence of HIV and syphilis among pregnant women attending labor ward of WSTRH. Data were analyzed by using SPSS version 20.0 software and result was summarized using means and percentages and presented by using figure and tables. Descriptive statistics were used. Result: Overall prevalence of sexually transmitted infection among pregnant women in labor was 7.4% from these HIV sero-prevalence accounts for 3.8% and VDRL positivity enumerates to be 3.7%. HIV-syphilis co-infection was found to be 0.9%. Higher sero-prevalence of HIV, syphilis and co-infection rate was reported in 2016, among age category of 35-44 years. Conclusion and recommendation: Significant percentage of HIV, syphilis sero-prevalence and co-infection rate was found in this study with increased proportion in 2016. Strong antenatal screening and appropriate strategies should be devised for prevention and control of HIV, syphilis, in women of reproductive age.

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Section: Discussionsupporting

confidence: 84%

“…More specifically, syphilis causes genital ulcer and facilitates HIV entry and shading. Besides, it induces immune activation and favor viral replication, which in turn accelerate HIV transmissibility [53].…”

Section: Discussionmentioning

confidence: 99%

Sero-Prevalence of HIV and Syphilis Infection Among Pregnant Mothers Attended Labor Ward at Wolaita Sodo University Teaching Referral Hospital: A Five-Year Retrospective Study (2012-2016)

Ageru¹

2018

AJHR

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“…This will undoubtedly lead to concentration of HIV positive pregnant women in this hospital and hence the observed higher prevalence. Secondly, the child bearing age also corresponds to the age of maximal sexual activity and has been found to have the highest incidence of HIV infection [ 21 ]. This prevalence is, however, about half of 12.7% reported by Chama et al [ 22 ] in 2010 among women attending antenatal clinic from the same hospital where this study was carried out.…”

Section: Discussionmentioning

confidence: 99%

Neonatal Tetanus Immunity in Nigeria: The Effect of HIV Infection on Serum Levels and Transplacental Transfer of Antibodies

Bashir

Elechi

Ashir

et al. 2016

Journal of Tropical Medicine

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Background. Tetanus toxoid immunisation of pregnant mother has remained the most effective strategy in eliminating neonatal tetanus. Impaired production and/or transplacental transfer of antibodies may affect the effectiveness of this strategy. We studied the effect of maternal HIV infection on serum levels and transplacental transfer of anti-tetanus antibodies. Methods. A total of 162 mother-baby paired serum samples were taken and analysed for anti-tetanus antibody levels using ELISA. Maternal HIV status was also determined by double ELISA technique. Maternal TT vaccination status was also documented. Results. Thirty-eight (23.5%) mothers and 41 (25.3%) babies were seronegative, out of whom 8 mothers were HIV positive and 9 babies were HIV exposed. HIV infected mothers and HIV exposed infants were, respectively, 16.27 times (OR = 16.27, 95% CI = 3.28 to 80.61) and 33.75 times (OR = 33.75, 95% CI = 4.12 to 276.40) more likely to be seronegative for anti-tetanus antibody. Similarly, HIV positive mother-newborn pairs were 7.46 times more likely to have a poor transplacental transfer of tetanus antibodies (OR = 7.46, 95% CI = 1.96 to 28.41). Conclusions. Maternal HIV infection is associated with impaired maternofoetal transfer of anti-tetanus antibodies and seronegativity among mothers and their newborns. Hence, this may hinder efforts to eliminate neonatal tetanus.

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“…However, without any interventions from gestation, infants who infected congenitally will grow up with pathogens, especially HBV and HIV [3] [4] [9], and transmit those to others at some stage of their lives. Infection of HIV and syphilis in infants often occur simultaneously due to the similar pathways of transmission (i.e., from the placenta) [10] [11] [12] [13] [14] [15]. Maternal co-infection with HIV and syphilis is dangerous.…”

Section: Introductionmentioning

confidence: 99%

Prevalence and predictors of HIV-syphilis co-infection among HIV-infected pregnant women in China, 2011-2018

Wang¹,

Wang

et al. 2020

Preprint

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Background The co-infection of Human Immunodeficiency Virus (HIV) and syphilis is risky for pregnant women and their expected children. In 2015, the Integrated Prevention of Mother-to-Child Transmission (iPMTCT) programwas established to offer all pregnant women with free screening, counseling, and testing of HIV and syphilis during regular obstetric inspections. To summarize the phase progress of this program, we reported the trends of maternal HIV-syphilis co-infection in China. We tried to socioeconomic factors associated with HIV-syphilis co-infection to inform the stratified control strategy for future work. Methods We obtained the prevalence data of HIV and syphilis over 2011–2018 by reviewing the Sexually Transmitted Infection (STI) monthly update reporting to the central surveillance system. With health status, background characteristics, and health outcomes reported, we collected the case reports from 2,578 HIV-positive pregnant women who accepted the screening at the local clinic. The trends of HIV and syphilis prevalence were examined using the Cochran-Armitage trend test. Logistic regression was applied to detect the features associated with syphilis infection among HIV-positive women and the potential risk factor to neonatal death. Results The prevalence of HIV decreased from 0.076–0.039% among registered pregnant women but increased slightly to 0.054% in 2018. The trend of syphilis prevalence in HIV-infected pregnant women fluctuated slightly around an average of 1.80% (p = .378). Multivariate logistic regression indicated finishing education of junior high school or below (aOR: 1.79, 95%CI: 1.31–2.43; p < .001), on regular Antiretroviral Therapy (ART) (aOR: 1.89, 95%CI: 1.47–2.45; p < .001) and exposed HIV from injective drug use (aOR: 5.49, 95%CI: 3.51–8.61; p < .001) are associated with high syphilis infection risk. Syphilis co-infection with HIV (aOR: 2.81, 95%CI: 1.32–5.96; p < .007) significantly increases the risk of newborns death. Conclusion Syphilis infection is still very prevalent in HIV-positive pregnant women five years after the implementation of iPMTCT program. Promoting the health education for maternal infection of STIs and increasing the availability of early intervention to link more marginalized women with care service should be the focuses of work in the next stage.

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Syphilis and Human Immunodeficiency Virus Co-infection among Pregnant Women in Nigeria: Prevalence and Trend

Cited by 5 publications

References 16 publications

Sero-Prevalence of HIV and Syphilis Infection Among Pregnant Mothers Attended Labor Ward at Wolaita Sodo University Teaching Referral Hospital: A Five-Year Retrospective Study (2012-2016)

Sero-Prevalence of HIV and Syphilis Infection Among Pregnant Mothers Attended Labor Ward at Wolaita Sodo University Teaching Referral Hospital: A Five-Year Retrospective Study (2012-2016)

Neonatal Tetanus Immunity in Nigeria: The Effect of HIV Infection on Serum Levels and Transplacental Transfer of Antibodies

Prevalence and predictors of HIV-syphilis co-infection among HIV-infected pregnant women in China, 2011-2018

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