Alkyne of magic: An efficient synthesis of (+)‐spirolaxine methyl ether (1) was accomplished by using alkynes as versatile synthetic building blocks. Highlights include two ProPhenol‐catalyzed asymmetric alkynylations and a Pd‐catalyzed spiroketalization (see scheme; TBS=tert‐butyldiphenylsilyl). The use of alkynes alleviates the chemoselectivity issues of ketones and should be widely applicable to natural product synthesis.