Synthetic Transformations of Sesquiterpene Lactones. 8*. Synthesis of 13-(2-Oxofuro- [2,3-d]pyrimidin-3(2H)-yl)eudesmanolides

Synthetic transformations of sesquiterpene lactones 9.* Synthesis of 13-(pyridinyl)eudesmanolides

“…1,2 Among the accessible methylidene lactones of eudesmane type are isoalantolactone (1), which has shown antibacterial, fungicidal, and antiproliferative activity. 3 Our studies of Heck reactions between the methylidene lactone 1 and aryl halides 4,5 or bromouracils 6 provide opportunities for the modification of lactone structure by introduction of aromatic or heteroaromatic substituents at position С-13 and preservation of α-methylidene-γ-lactone moiety in the molecule.…”