Synthetic study of curacin A: synthesis of partial structure of curacin A and elucidation of the absolute stereochemistry at the methylcyclopropylthiazoline moiety

Interaction of the cyanobacterial thiazoline-containing lipid curacin A with bovine brain tubulin

“…This could certainly be true for curacin A. It is likely that the long side chain of the curacin A plays a role in binding tubulin and stabilizing the molecule; in fact, the long side chain has recently been shown to be an essential structural component for the drug to retain inhibition of microtubule assembly [Onoda et al, 1995].…”