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“…BAY-61-3606, identified by Yamamoto et al, is an imidazopyrimidine analogue that selectively inhibits Syk activity to treat allergic diseases [96]. Pyrimidine-5-carboxamides families, such as YM193306 and other derivatives developed by Hisamichi et al are also Syk inhibitors to treat allergic diseases [97]. …”
Section: Syk-targeted Drug Developmentmentioning
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“…BAY-61-3606, identified by Yamamoto et al, is an imidazopyrimidine analogue that selectively inhibits Syk activity to treat allergic diseases [96]. Pyrimidine-5-carboxamides families, such as YM193306 and other derivatives developed by Hisamichi et al are also Syk inhibitors to treat allergic diseases [97]. …”
Section: Syk-targeted Drug Developmentmentioning
“…The effect of MNS on the osteosarcoma cell lines was compared with a src inhibitor and three additional syk inhibitors [12, 31, 32]. Although the effect of MNS was confirmed in these experiments (Figures 8(a)–8(c)), neither the src or other syk inhibitors, alone or in combination, mimicked the effects of MNS on motility (Figure 8(a)) or colony formation (Figures 8(b) and 8(c)).…”
Section: Resultsmentioning
“…One such derivative, 2-(2-aminoethylamino)-4-{3-(trifluoromethyl)phenylamino}pyrimidine-5-carboxamide, exhibited significant inhibition of the PCA reaction in mice following subcutaneous administration (Hisamichi et al, 2005). Another potent Syk kinase inhibitor, namely R112, from the 2,4-diaminopyrimidine class, inhibited degranulation induced by anti IgE crosslinking in both mast cells and basophils, uniquely inhibiting not only degranulation, but also lipid mediator and cytokine production.…”
Section: {2-[7-(34-dimethoxyphenyl)-imidazo[12-c] Pyrimidin-5-ylamimentioning