Synthetic Studies on Indoles and Related Compounds. Part 53. A Total Synthesis of 1‐Methoxycanthin‐6‐one: An Efficient One‐Pot Synthesis of the Canthin‐6‐one Skeleton from β‐Carboline‐1‐carbaldehyde.

Abstract

Alkaloids U 0600 Synthetic Studies on Indoles and Related Compounds. Part 53. A Total Synthesis of 1-Methoxycanthin-6-one: An Efficient One-Pot Synthesis of the Canthin-6-one Skeleton from β-Carboline-1-carbaldehyde. -The approach allows an efficient synthesis of the parent compound (IIIa) and the title compound (IIIb). -(SUZUKI*, H.; ADACHI, M.; EBIHARA, Y.; GYOUTOKU, H.; FURUYA, H.; MURAKAMI, Y.; OKUNO, H.; Synthesis 2005, 1, 28-32; Sch. Pharm. Sci., Toho Univ., Funabashi, Chiba 274, Japan; Eng.) -C. Herrmann 21-209

Recent Advances in the Studies on Luotonins

“…Although numerous synthetic procedures for the parent canthin-6-one core have been reported [51,52,53,54], only one synthetic procedure for luotonin C and D has been published [4]. Luotonin C and D were first prepared in two steps by a biomimetic way from harmine coexisting with these alkaloids in the same plant source.…”