Synthetic studies of phosphoinositides

Stepanov, A. E.; Швец, В. И.

doi:10.1016/0009-3084(79)90110-5

Cited by 27 publications

(8 citation statements)

References 21 publications

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“…(20) It has been reported that in the presence of A1C13 an a,0-unsaturated ketone underwent a similar reaction with furan derivative: Buchta, E.; Bayer, W. Naturwissenschaften 1959, 46, 14. 60 instrument. IR spectra were obtained for neat liquids (2)(3)(4)(5)(6)(7)(8) or KBr disks (9 and 10) on a Hitachi 260-10 DR spectrophotometer.…”

Section: Methodsmentioning

confidence: 99%

1,1,1-Trifluoro-2-penten-4-one as a building block of trifluoromethyl-substituted compounds

Ogoshi¹,

Mizushima²,

Toi³

et al. 1986

J. Org. Chem.

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Polar fraction b eluted with hexane-ether and yielded 0.345 g (77%) of a diastereomeric mixture of (±)-l-(4-(dimethyl-tertbutylsiloxy)-2,2,6,6-tetramethylcyclohexylidene)-2,3-dihydroxy-3-methyl-2-phenylbutane (16) as a viscous oil: IR (film) 3500, 3070 (w), 3050 (w), 3025 (w), 2900 (m), 1940 (w), 1870 (w), 1800 (w), 1600,1470 (m), and 1400-725 cm"1; NMR 0.07 (s, 3 H), 0.08 (s, 3 ), 0.75, 0.80 (2 s, 3 H, in the ratio of 1:3), 0.90, 0.91 (2 s, 9 ), 1.10-1.90 (m, 23 H, including several CHS singlets),

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Section: Methodsmentioning

confidence: 99%

1,1,1-Trifluoro-2-penten-4-one as a building block of trifluoromethyl-substituted compounds

Ogoshi¹,

Mizushima²,

Toi³

et al. 1986

J. Org. Chem.

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“…Результаты исследований последних лет свидетельствуют, что цитомегаловирусная инфекция (ЦМВИ)наиболее часто встречаемое вирусное заболевание при беременности. Возбудитель вируса герпеса и цитомегалии активно размножается в плаценте, повреждая ее, проникает через плацентарный барьер и вызывает внутриутробное поражение плода, что в свою очередь приводит к плацентарной недостаточности, воспалительным изменениям в органах и тканях плода, задержке его роста [2,8,13,14].…”

Section: Summary the Role Of Cholesterol And Estradiol In The Developunclassified

“…Ключевые слова: цитомегаловирусная инфекция, плацентарная недостаточность, холестерол, эстрадиол. Липиды -большая группа природных соединений, находящихся в составе клеточных структур всех живых организмов, которые наряду с белками, нуклеиновыми кислотами и углеводами обеспечивают основные функции процессов жизнедеятельности [13]. При беременности липиды являются основным энергетическим и структурным материалом, идущим на построение организма плода, а также исходными продуктами для синтеза биологически активных веществ -эйкозаноидов [9,11].…”

unclassified

The Role of Cholesterol and Estradiol in the Development of Placental Insufficiency Under Cytomegalovirus Infection in the Third Trimester of Pregnancy

Ishutina¹,

Луценко²,

Andrievskaya³

2017

Bulletin Physiology and Pathology of Respiration

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To assess the role of cholesterol and estradiol in the development of placental insufficiency under cytomegalovirus infection (CMVI) in the period of gestation, cholesterol and estradiol were studied in the peripheral blood of 35 pregnant women who had a reactivation of chronic CMVI (IgG antibody titer to CMV is 1:1600) in the third trimester of pregnancy (the main group). As a control the blood plasma of 35 healthy women of the same period of gestation and age as in the main group were studied. It was found out that the reactivation of chronic CMVI in the third trimester of gestation was followed by the decrease of concentration of cholesterol by 23% ( p<0.001), of estradiol by 65% (p<0.001) in comparison with the values of healthy women. To analyze the chosen values for assessment, the discriminant function was found. It had the probability of differences not less than 95%; which that the discriminant equation was derived which for this study had the following formula: D=(-379×total cholesterol)+(-0.072×estradiol), where D is a discriminant function whose limit value is (-2673.59). If D is equal or less than the limit value, then the development of placental insufficiency in women in the third trimester of pregnancy is predicted, and if D is more than the limit value, then the normal course of the third trimester of pregnancy is predicted. Thus, the obtained results allow to establish the main role of disturbances of total cholesterol contents and key steroid hormone of pregnancy (estradiol) in the pathogenesis of placental insufficiency development under CMVI during gestation, which can be the basis for improvement of diagnostic and medical basis under this pathology of pregnant women.

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“…Phospholipid antigens isolated from pathogenic bacteria Mycobacterium were identified as phosphatidylinositol mannosides, and are used as components of diagnostic reagents for tuberculosis and leprosy (14)(15)(16). Continuing our program aimed at synthesis of novel biologically active myoinositol derivatives, we took advantage of some recently developed methods in the chemistry of carbohydrates and lipids to accomplish the total synthesis deaza-analog of GPIs.…”

Section: Syntheses Of Phosphatidylinositol β-D-glucosaminidesmentioning

confidence: 99%

Synthesis of Inositol-Containing Glycophospholipids with Natural and Modified Structure

Stepanov¹,

Швец²

1998

ACS Symposium Series

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Synthetic studies of phosphoinositides

Cited by 27 publications

References 21 publications

1,1,1-Trifluoro-2-penten-4-one as a building block of trifluoromethyl-substituted compounds

1,1,1-Trifluoro-2-penten-4-one as a building block of trifluoromethyl-substituted compounds

The Role of Cholesterol and Estradiol in the Development of Placental Insufficiency Under Cytomegalovirus Infection in the Third Trimester of Pregnancy

Synthesis of Inositol-Containing Glycophospholipids with Natural and Modified Structure

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