Synthetic Studies of cis‐4‐Amino‐L‐proline Derivatives as Novel Lipid Lowering Agents.

Abstract

Amino acidsAmino acids U 0400 Synthetic Studies of cis-4-Amino-L-proline Derivatives as Novel Lipid Lowering Agents. -cis-4-Amino-L-proline based triglycerides lowering agents of general structures (V) and (VIII) are designed and synthesized as potential lipid lowering compounds. The novel compounds are not able to activate PPAR significantly. Compounds (VI) and (VIII) display moderate activity towards triglyceride lowering. -(DAS*, S. K.; KROVVIDI, V. L. N. R.; JAGADHESHAN, H.; IQBAL, J.; Bioorg. Med. Chem.