Synthetic strategies of pyridazino[4,5-b]indoles

Abstract

Pyridazino [4,5-b]indole is an important class of heterocyclic compounds with numerous applications in the field of medicinal chemistry. This review summarizes the synthetic methods of pyridazino [4,5-b]indoles published during the period from 1962 to 2022. In this review, we have discussed different methods for the synthesis of pyridazino [4,5-b]indole from various starting materials and the difficulties that scientists faced during the preparation process. We focus on the recent developments in synthetic methods of the pyridazino [4,5-b]indoles. Pyridazino[4,5-b]indoles Biological importance of pyridazino[4,5-b]indoles ✓ As anxiolytic ✓ As antihypertensive ✓ As thromboxane A2 synthetase inhibitors ✓ As antihistaminic ✓ As HIV-1 reverse transcriptase inhibitors ✓ As antiarrhythmics ✓ As phosphatidylinositol 3-kinase (PI3K) inhibitors ✓ As blood platelet aggregation inhibitors

Design Synthesis and Characterization of Novel Quinazolin-4(3H)-one Derivatives with Anticipated Pharmacological Efficacy

“…The recently synthesized compounds' antibacterial efficacy was also assessed. The results indicated that some of these compounds have moderate activity towards bacteria [8]. As part of our research, we are interested in construction of new synthetic pathways for a range of quinazolinone substrates that have interesting biological and pharmacological properties [9][10][11][12][13][14][15][16][17][18][19][20][21][22][23][24][25][26][27], In this article, we provide a report.…”