Synthetic strategies in the construction of chromones

Abstract

magnified image Because of important biological applications of chromones, some synthetic strategies leading to more complex derivatives have been widely explored in the past years. Thus, the purpose of this review is to report some recent improvements of the classical synthetic methods and of some nonclassical methods to obtain simple oxygenated chromones. The strategies for synthesis of heterocycle analogs containing phosphorus, nitrogen, and sulfur are also summarized. J. Heterocyclic Chem., (2010).

Synthesis and Transformation of Halochromones

“…Among the methodologies developed over the years for the synthesis of chromones, the most efficient are the Claisen condensation, Baker-Venkataraman and Kostanecki-Robinson methods [54,55]. The synthesis of halochromones can be carried out by applying the general methods for the synthesis of chromones using halogenated precursors or by halogenation of the chromone nucleus in a final stage.…”

Microwaves in Heterocyclic Chemistry

“…Coumarins, dihydrocoumarins, flavones, and chromones [130] are important heterocyclic compounds widely distributed in the plant kingdom. These compounds have various bioactivities and applications in cosmetics, pharmaceuticals, food, flavorings, and agrochemicals.…”

A novel sulfonyl chromen‐4‐ones (CHW09) preferentially kills oral cancer cells showing apoptosis, oxidative stress, and DNA damage

“…Functionalized chromones are the key component of naturally occurring oxygenated heterocycles which possess various biological activities . Chromones are also excellent templates to perform structural modifications, allowing the synthesis of a wide array of molecules with diverse pharmacological activities .…”