Synthetic, Spectroscopic, and Biological Aspects of Triorganosilicon(IV) Complexes of Tridentate Schiff Bases

Devi, Jai; Kumari, Suman; Asijaa, Sonika; Malhotra, Rajesh

doi:10.1080/10426507.2012.686546

Cited by 19 publications

(8 citation statements)

References 10 publications

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“…10 We are more concerned with the antimicrobial activity of organotin(IV) compounds, keeping this in mind and in continuation of our work, on the synthesis of biologically active compounds containing N, O, S, and their organotin/silicon complexes. [11][12][13][14] We report the synthesis of new complexes of Schiff bases derived from the condensation of pyridoxal hydrochloride with derivatives of aminophenol and studied the effect of introducing tin on the activity of the ligand.…”

Section: Introductionmentioning

confidence: 99%

Bioactive Penta-Coordinated Diorganotin(Iv) Complexes of Pyridoxalimine Schiff Bases

Asijaa

Malhotra

2012

Phosphorus, Sulfur, and Silicon and the Related Elements

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N CH 2 OH H C O CH 3 N O R Sn R R Abstract Diorganotin(IV) complexes of an extended system derived from the condensation of pyridoxal hydrochloride physical data evidenced the formation of penta-coordinated species with the ligands acting as tridentate (ONO) with oxygen occupying the axial positions, and nitrogen at one of the equatorial positions. The ligands and their organotin complexes have been evaluated for antimicrobial activity against phytopathogenic fungi Candida albicans and Aspergillus niger at 25 ± 1 • C and bacteria Bacillus subtilis, Escherichia coli, and Staphylococcus aureus at 37 ± 1 • C. The activities of the ligands have been enhanced on complexation and the results indicate that they exhibit significant antimicrobial properties.

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Section: Introductionmentioning

confidence: 99%

Bioactive Penta-Coordinated Diorganotin(Iv) Complexes of Pyridoxalimine Schiff Bases

Asijaa

Malhotra

2012

Phosphorus, Sulfur, and Silicon and the Related Elements

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“…Analytical data suggested the formation of brownish and purple‐colored solid complexes in 1:1 and 1:2 molar ratios. Molar conductance values of the complexes were found to be less than 18 ohm −1 cm 2 mol −1 suggesting their nonelectrolytic nature . Some of the compounds were soluble in MeOH, EtOH, and others in CDCl 3 , DMF, and DMSO.…”

Section: Resultsmentioning

confidence: 96%

“… Phenyl derivatives were found to be more active having highest zone of inhibition and lowest MIC as compared to other derivatives against all the bacterial strains. This may be due to the bulkiness of substituent R, which increases the lipophilicity coupled with the polarity of M–C bond, which amplify the biological activity of these complexes in the order Ph > Bu > Et ≥ Me In addition, phenyl group exhibited π–π interaction, which played a key role in increasing the bioactivity. On comparing the data, triphenyl derivatives display better biological activity than diphenyl analogs. On the basis of these findings, compounds 4 , 5 , 9 , 12 , 13 , 16 , and 17 were found to be more active than standard drug ciprofloxacin and compound 17 was found to be the most active with minimum MIC (0.003 μmol/mL) and maximum zone of inhibition (20 mm) in the entire series.…”

Section: Resultsmentioning

confidence: 99%

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Synthesis, characterization, and quantitative structure–activity relationship studies of bioactive dehydroacetic acid and amino ether Schiff base complexes

Devi

Kumar

2016

Heteroatom Chemistry

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Structural aspects of organosilicon(IV) and organotin(IV) complexes with dehydroacetic acid and amino ether Schiff base ligand have been described with the help of elemental analyses, conductance measurements, UV–Vis, infrared, multinuclear magnetic resonance, mass spectroscopy as well as thermogravimetric analysis, and X‐ray diffraction studies. Analysis of data suggested that the Schiff base provides two bidentate NO domains and was coordinated to silicon and tin moiety through the imine nitrogen and hydroxyl oxygen atom. Complexes were found to be nonelectrolytic and monomeric in nature. The thermal decomposition for tin compounds occurred in two steps and resulted into the formation of pure SnO2 as end product. The in vitro biological effects of the synthesized compounds were tested against two Gram‐positive and two Gram‐negative bacteria. The results of biological activity showed that all the complexes have enhanced activity as compared with the corresponding ligand, and compounds 5, 9, 11, 12, 13, 15, 16, and 17 were more potent than the standard drug ciprofloxacin. Compound 17 exhibited best antibacterial activity with lowest minimum inhibitory concentration value and maximum zone of inhibition. Further, quantitative structure–activity relationship studies pointed out that more stable compound were more active as antibacterial agents.

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“…It has been reported that many compounds show a marked enhancement in pharmacological and toxicological properties when combined with metal ions . In continuation of our research work on the study of the chelation effect on biologically active molecules, we herein report some new Schiff base ligands derived from the condensation of aminothiazole and salicylaldehyde derivatives and their metal complexes to study their antibacterial and cytotoxic properties.…”

Section: Introductionmentioning

confidence: 97%

Co(II), Ni(II), Cu(II) and Zn(II) complexes of aminothiazole‐derived Schiff base ligands: Synthesis, characterization, antibacterial and cytotoxicity evaluation, bovine serum albumin binding and density functional theory studies

Prakash

Malhotra

2017

Applied Organom Chemis

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Transition metal complexes of type M(L)2(H2O)x were synthesized, where L is deprotonated Schiff base 2,4‐dihalo‐6‐(substituted thiazol‐2‐ylimino)methylphenol derived from the condensation of aminothiazole or its derivatives with 2‐hydroxy‐3‐halobenzaldehyde and M = Co2+, Ni2+, Cu2+ and Zn2+ (x = 0 for Cu2+ and Zn2+; x = 2 for Co2+ and Ni2+). The synthesized Schiff bases and their metal complexes were thoroughly characterized using infrared, 1H NMR, electronic and electron paramagnetic resonance spectroscopies, elemental analysis, molar conductance and magnetic susceptibility measurements, thermogravimetric analysis and scanning electron microscopy. The results reveal that the bidentate ligands form complexes having octahedral geometry around Co2+ and Ni2+ metal ions while the geometry around Cu2+ and Zn2+ metal ions is four‐coordinated. The geometries of newly synthesized Schiff bases and their metal complexes were fully optimized in Gaussian 09 using 6–31 + g(d,p) basis set. Fluorescence quenching data reveal that Zn(II) and Cu(II) complexes bind more strongly to bovine serum albumin in comparison to Co(II) and Ni(II) complexes. The ligands and their complexes were evaluated for in vitro antibacterial activity against Escherichia coli ATCC 25922 (Gram negative) and Staphylococcus aureus ATCC 29213 (Gram positive) and cytotoxicity against lever hepatocellular cell line HepG2.

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Synthetic, Spectroscopic, and Biological Aspects of Triorganosilicon(IV) Complexes of Tridentate Schiff Bases

Cited by 19 publications

References 10 publications

Bioactive Penta-Coordinated Diorganotin(Iv) Complexes of Pyridoxalimine Schiff Bases

Bioactive Penta-Coordinated Diorganotin(Iv) Complexes of Pyridoxalimine Schiff Bases

Synthesis, characterization, and quantitative structure–activity relationship studies of bioactive dehydroacetic acid and amino ether Schiff base complexes

Co(II), Ni(II), Cu(II) and Zn(II) complexes of aminothiazole‐derived Schiff base ligands: Synthesis, characterization, antibacterial and cytotoxicity evaluation, bovine serum albumin binding and density functional theory studies

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