Synthetic recovery of impulse propagation in myocardial infarction via silicon carbide semiconductive nanowires

Abstract

Myocardial infarction causes 7.3 million deaths worldwide, mostly for fibrillation that electrically originates from the damaged areas of the left ventricle. Conventional cardiac bypass graft and percutaneous coronary interventions allow reperfusion of the downstream tissue but do not counteract the bioelectrical alteration originated from the infarct area. Genetic, cellular, and tissue engineering therapies are promising avenues but require days/months for permitting proper functional tissue regeneration. Here we engineered biocompatible silicon carbide semiconductive nanowires that synthetically couple, via membrane nanobridge formations, isolated beating cardiomyocytes over distance, restoring physiological cell-cell conductance, thereby permitting the synchronization of bioelectrical activity in otherwise uncoupled cells. Local in-situ multiple injections of nanowires in the left ventricular infarcted regions allow rapid reinstatement of impulse propagation across damaged areas and recover electrogram parameters and conduction velocity. Here we propose this nanomedical intervention as a strategy for reducing ventricular arrhythmia after acute myocardial infarction.

Myofibroblasts impair myocardial impulse propagation by heterocellular connexin43 gap-junctional coupling through micropores

“…Such interventions would be promising to improve the depressed impulse propagation and reduce the spatiotemporally inhomogeneous electrical conduction on the infarct border zone and could attenuate genesis of re-entrant arrhythmias. In conjunction with this in vivo study, Lagonegro et al demonstrated a unique therapeutic intervention against arrhythmogenesis; local in-situ injection of multiple nanowires into the cryoinjured zone improved the depressed impulse conduction of the mouse heart (Lagonegro et al, 2022). Further studies are required to determine the feasibility of these promising strategies.…”

Investigating the Corrosion Resistance of Different SiC Crystal Types: From Energy Sectors to Advanced Applications

“…(3) Environmentally Friendly Applications . Exploration of new applications of SiC in clean energy, biomedicine, and environmental purification. − While improving product quality, optimize the production process to reduce environmental pollution. − …”

Advances in the design, generation, and application of tissue-engineered myocardial equivalents

“…Polymers (polyaniline and polypyrrole) and materials (MXene, graphene oxide, carbon nanotubes, gold nanorods/wires, poly(3,4-ethylenedioxythiophene):polystyrene sulfonate, silicon carbide nanowires, polyvinylidene fluoride, etc. ) were selected for their semiconductor or piezoelectric behavior to improve electrophysiological differentiation and synchronize the beating of cultured CMs and their precursors ( Dvir et al, 2011 ; Zhang et al, 2017a ; Tomecka et al, 2017 ; Ye et al, 2020 ; Alegret et al, 2022 ; Lagonegro et al, 2022 ; Mancino et al, 2022 ; Zhao et al, 2022 ; Ul Haq et al, 2023 ; Wu et al, 2023 ; Yin and Jiang, 2023 ). Of interest, various of these materials have been combined with bioinspired adhesive proteins derived from mussels, as dopamine used a crosslinker to reach improved superelastic and mechanical features of scaffolds based on polypyrrole or MXene ( Wang et al, 2016 ; Ye et al, 2020 ).…”