Synthetic post-translational modification of histones

Nadal, Simon; Raj, Ritu; Mohammed, Shabaz; Davis, Benjamin G.

doi:10.1016/j.cbpa.2018.02.004

Cited by 54 publications

(46 citation statements)

References 109 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Histone posttranslational modifications, like acetylation and methylation, play a key role in the regulation of gene expression [30]. These characteristics are crucial for important biological processes like the actions of immune system, in which HDACs modulate the gene expression of toll-like receptors (TLRs) and interferon (IFN) signaling pathways [31].…”

Section: Histone-deacetylases Inhibitors and Neuroimmune Alterationsmentioning

confidence: 99%

Neuroimmune Alterations in Autism: A Translational Analysis Focusing on the Animal Model of Autism Induced by Prenatal Exposure to Valproic Acid

Deckmann

Schwingel

Fontes-Dutra

et al. 2018

Neuroimmunomodulation

View full text Add to dashboard Cite

Autism spectrum disorder (ASD) is a highly prevalent developmental disorder characterized by deficits in communication and social interaction and in stereotyped or repetitive behaviors. Besides the classical behavioral dyad, several comorbidities are frequently present in patients with ASD, such as anxiety, epilepsy, sleep disturbances, and gastrointestinal tract dysfunction. Although the etiology of ASD remains unclear, there is supporting evidence for the involvement of both genetic and environmental factors. Valproic acid (VPA) is an anticonvulsant and mood stabilizer that, when used during the gestational period, increases the risk of ASD in the offspring. The animal model of autism induced by prenatal exposure to VPA demonstrates important structural and behavioral features that can be observed in individuals with autism; it is thus an excellent tool for testing new drug targets and developing novel behavioral and drug therapies. In addition, immunological alterations during pregnancy could affect the developing embryo because immune molecules can pass through the placental barrier. In fact, exposure to pathogens during the pregnancy is a known risk factor for ASD, and maternal immune activation can lead to autistic-like features in animals. Interestingly, neuroimmune alterations are common in both autistic individuals and in animal models of ASD. We summarize here the important alterations in inflammatory markers, such as cytokines and chemokines, in patients with ASD and in the VPA animal model.

show abstract

Section: Histone-deacetylases Inhibitors and Neuroimmune Alterationsmentioning

confidence: 99%

Neuroimmune Alterations in Autism: A Translational Analysis Focusing on the Animal Model of Autism Induced by Prenatal Exposure to Valproic Acid

Deckmann

Schwingel

Fontes-Dutra

et al. 2018

Neuroimmunomodulation

View full text Add to dashboard Cite

show abstract

“…Many post-translational modifications are mediated by sirtuins [6,7]. SIRT3 is a member of a family of seven sirtuins (1–7) that are collectively referred to as the cellular acylome [21].…”

Section: The Melatonin/sirt3 Interactionsmentioning

confidence: 99%

“…This suggests that epigenetic processes may account for the greater molecular heterogeneity than that which is apparent in organisms [3,4]. Within recent decades, unraveling the mechanisms whereby the large variety of epigenetic modifications (post-translational modifications) are achieved has been a major area of research [5,6,7]. …”

Section: Introductionmentioning

confidence: 99%

Melatonin Mitigates Mitochondrial Meltdown: Interactions with SIRT3

Reíter

Tan

Rosales-Corral

et al. 2018

IJMS

View full text Add to dashboard Cite

Melatonin exhibits extraordinary diversity in terms of its functions and distribution. When discovered, it was thought to be uniquely of pineal gland origin. Subsequently, melatonin synthesis was identified in a variety of organs and recently it was shown to be produced in the mitochondria. Since mitochondria exist in every cell, with a few exceptions, it means that every vertebrate, invertebrate, and plant cell produces melatonin. The mitochondrial synthesis of melatonin is not photoperiod-dependent, but it may be inducible under conditions of stress. Mitochondria-produced melatonin is not released into the systemic circulation, but rather is used primarily in its cell of origin. Melatonin’s functions in the mitochondria are highly diverse, not unlike those of sirtuin 3 (SIRT3). SIRT3 is an NAD+-dependent deacetylase which regulates, among many functions, the redox state of the mitochondria. Recent data proves that melatonin and SIRT3 post-translationally collaborate in regulating free radical generation and removal from mitochondria. Since melatonin and SIRT3 have cohabitated in the mitochondria for many eons, we predict that these molecules interact in many other ways to control mitochondrial physiology. It is predicted that these mutual functions will be intensely investigated in the next decade and importantly, we assume that the findings will have significant applications for preventing/delaying some age-related diseases and aging itself.

show abstract

“…In the following, labeling strategies for the most-important cytosine modifications will be discussed. Covalent labeling schemes for histone tails are still in early development and were not yet utilized for analytical work [20,21]. …”

Section: Covalent Labelingmentioning

confidence: 99%

Analytical epigenetics: single-molecule optical detection of DNA and histone modifications

Heck

Michaeli

Bald

et al. 2019

Current Opinion in Biotechnology

View full text Add to dashboard Cite

The field of epigenetics describes the relationship between genotype and phenotype, by regulating gene expression without changing the canonical base sequence of DNA. It deals with molecular genomic information that is encoded by a rich repertoire of chemical modifications and molecular interactions. This regulation involves DNA, RNA and proteins that are enzymatically tagged with small molecular groups that alter their physical and chemical properties. It is now clear that epigenetic alterations are involved in development and disease, and thus, are the focus of intensive research. The ability to record epigenetic changes and quantify them in rare medical samples is critical for next generation diagnostics. Optical detection offers the ultimate single-molecule sensitivity and the potential for spectral multiplexing. Here we review recent progress in ultrasensitive optical detection of DNA and histone modifications.

show abstract

Synthetic post-translational modification of histones

Cited by 54 publications

References 109 publications

Neuroimmune Alterations in Autism: A Translational Analysis Focusing on the Animal Model of Autism Induced by Prenatal Exposure to Valproic Acid

Neuroimmune Alterations in Autism: A Translational Analysis Focusing on the Animal Model of Autism Induced by Prenatal Exposure to Valproic Acid

Melatonin Mitigates Mitochondrial Meltdown: Interactions with SIRT3

Analytical epigenetics: single-molecule optical detection of DNA and histone modifications

Contact Info

Product

Resources

About