Synthetic Polymer as an Adjuvant in Collagen‐Induced Arthritis

Shakya, Akhilesh Kumar; Nandakumar, Kutty Selva

doi:10.1002/9780470942390.mo130226

Cited by 8 publications

(5 citation statements)

References 49 publications

(58 reference statements)

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“…This study demonstrated the feasibility of in vitro cartilage regeneration using chondrocyte-loaded hydrogel, but failed to provide related evidence about the chondrogenic regulation of BMSCs. In the concurrent study, we adopted the collagenase digestion strategy as a water-soluble treatment to decrease the negative effect of type Ⅱ collagen triggering inflammation [ 50 , 51 ]. Additionally, ColMA derived from skin was further added to counteract the dramatic loss of collagen components caused by collagenase digestion ( Fig.…”

Section: Discussionmentioning

confidence: 99%

Fabrication of biphasic cartilage-bone integrated scaffolds based on tissue-specific photo-crosslinkable acellular matrix hydrogels

Hua

Huo

Bai³

et al. 2022

Materials Today Bio

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Section: Discussionmentioning

confidence: 99%

Fabrication of biphasic cartilage-bone integrated scaffolds based on tissue-specific photo-crosslinkable acellular matrix hydrogels

Hua

Huo

Bai³

et al. 2022

Materials Today Bio

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“…This temperature is known as the lower critical solution temperature (LCST). Below this temperature, the polymer exists in a solution state and starts precipitating or becoming turbid above this temperature, and thus, this is also termed the cloud point (figure 2) [14][15][16][17][18]. The LCST is an intrinsic property of the thermo-responsive polymer, which is unchanged by physical mixing of the polymer with an enzyme.…”

Section: Thermo or Temperature-responsive Biocatalystsmentioning

confidence: 99%

An update on smart biocatalysts for industrial and biomedical applications

Shakya

Nandakumar

2018

J. R. Soc. Interface.

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Recently, smart biocatalysts, where enzymes are conjugated to stimuli-responsive (smart) polymers, have gained significant attention. Based on the presence or absence of external stimuli, the polymer attached to the enzyme changes its conformation to protect the enzyme from the external environment and regulate the enzyme activity, thus acting as a molecular switch. Owing to this behaviour, smart biocatalysts can be separated easily from a reaction mixture and re-used several times. Several such smart polymer-based biocatalysts have been developed for industrial and biomedical applications. In addition, they have been used in biosensors, biometrics and nano-electronic devices. This review article covers recent advances in developing different kinds of stimuli-responsive enzyme bioconjugates, including conjugation strategies, and their applications.

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“…The concentration of DELP (mg/ml) needed for 50 percent block (IC 50 ) of superoxide radicals, DPPH and NO were 1, 1.5, and 1.5 in that order. Total Phenolic Content was 25microgram GAE/mg [70].…”

Section: Model For Inflammatory Activity Arachidonic Acid-induced Modelmentioning

confidence: 99%

Recent and advanced animal models used in the Screening of analgesics and anti-inflammatory activity

Krishna¹,

Maurya²

2018

IJPBR

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Non-Steroidal anti-inflammatory drugs (NSAIDs) are consisting of three major anti-pyretic, anti-inflammatory and anti-analgesics properties. They have reduced the sensation of pain, body temperature, and inflammation. It is also used for the treatment of the long-term health problems like arthritis (rheumatoid arthritis, osteoarthritis, and lupus). NSAIDs highly protect the lining of the stomach and intestines from the damaging effects of acid promote blood clotting by activating blood platelets, and promote normal function of the kidney. Incompatible with the action of NSAIDs many different types of drugs and plant use for the treatment of the analgesic, inflammation and pyretic activity. Diclofenac inhibit the cyclooxygenase (COX-2) enzyme with the greater potency that it (COX-1). NSAIDs are generally used in the management of pain because of the integrated role of the COX pathway that is recognition of pyretic, inflammation and analgesic. Introduction to painful procedures and/or stressors during the early neonatal period can reprogram the underlying neurocircuitry involved in nociception and neuropathic pain perception. The reprogramming of these systems can result in an enduring elevation in sympathy towards mechanical and thermal stimuli. During adolescence, hind paw mechanical removal thresholds were evaluated using an electronic von Frey Anesthesiometer. Animals challenged neonatally with LPS (nLPS) had increased pain sensitivity on this measure which was related with decreased Oprm1 expression in the prefrontal cortex (PFC) and periaqueductal gray (PAG) of both male and female rats. There was no effect of inflammatory treatment on either anxiety or depressive-like behavior suggesting that affective functioning did not account for differences in mechanical pain sensitivity.

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Synthetic Polymer as an Adjuvant in Collagen‐Induced Arthritis

Cited by 8 publications

References 49 publications

Fabrication of biphasic cartilage-bone integrated scaffolds based on tissue-specific photo-crosslinkable acellular matrix hydrogels

Fabrication of biphasic cartilage-bone integrated scaffolds based on tissue-specific photo-crosslinkable acellular matrix hydrogels

An update on smart biocatalysts for industrial and biomedical applications

Recent and advanced animal models used in the Screening of analgesics and anti-inflammatory activity

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