Synthetic Polyacrylate Polymers as Particulate Intranasal Vaccine Delivery Systems for the Induction of Mucosal Immune Response

Zaman, Mehfuz; Simerská, Pavla; Tóth, István

doi:10.2174/156720110791011846

Cited by 21 publications

(16 citation statements)

References 63 publications

(147 reference statements)

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“…The success of intranasally delivered mucosal vaccines has been also limited by lack of effective vaccine formulations or delivery systems suitable for use in humans. Nowadays, the properties of polyacrylate polymer-based particulate systems are studied to facilitate mucosal immune responses [13]. However, conventional vaccinations involve subcutaneous or intradermal inoculations.…”

Section: Physical Approaches For Dna Plasmid Deliverymentioning

confidence: 99%

Improvement of different vaccine delivery systems for cancer therapy

2011

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Cancer vaccines are the promising tools in the hands of the clinical oncologist. Many tumor-associated antigens are excellent targets for immune therapy and vaccine design. Optimally designed cancer vaccines should combine the best tumor antigens with the most effective immunotherapy agents and/or delivery strategies to achieve positive clinical results. Various vaccine delivery systems such as different routes of immunization and physical/chemical delivery methods have been used in cancer therapy with the goal to induce immunity against tumor-associated antigens. Two basic delivery approaches including physical delivery to achieve higher levels of antigen production and formulation with microparticles to target antigen-presenting cells (APCs) have demonstrated to be effective in animal models. New developments in vaccine delivery systems will improve the efficiency of clinical trials in the near future. Among them, nanoparticles (NPs) such as dendrimers, polymeric NPs, metallic NPs, magnetic NPs and quantum dots have emerged as effective vaccine adjuvants for infectious diseases and cancer therapy. Furthermore, cell-penetrating peptides (CPP) have been known as attractive carrier having applications in drug delivery, gene transfer and DNA vaccination. This review will focus on the utilization of different vaccine delivery systems for prevention or treatment of cancer. We will discuss their clinical applications and the future prospects for cancer vaccine development.

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Section: Physical Approaches For Dna Plasmid Deliverymentioning

confidence: 99%

Improvement of different vaccine delivery systems for cancer therapy

2011

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“…LCP is designed to incorporate antigen, carrier, and adjuvant in a single molecular entity. The mode of action of LCP-based vaccine candidates has been analysed and it was found that, similar to other lipopeptides, the self-adjuvanting activity of constructs was based on TLR2 mediated DC activation [82]–[84]. Studies have shown that incorporation of a monomeric peptide epitope into a LCP structure could enhanced antibody immunogenicity up to 3200-fold in a mouse model of Chlamydia [34] and that the magnitude and specificity of the LCP-induced antibody responses could be influenced by the number of epitope sequences attached to the oligomeric polylysine core, the number of lipoamino acids in the constructs, the length of the alkyl side-chains, or the spacing between the lipoamino acid units [33], [35].…”

Section: Discussionmentioning

confidence: 99%

Vaccination with Lipid Core Peptides Fails to Induce Epitope-Specific T Cell Responses but Confers Non-Specific Protective Immunity in a Malaria Model

et al. 2012

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Vaccines against many pathogens for which conventional approaches have failed remain an unmet public health priority. Synthetic peptide-based vaccines offer an attractive alternative to whole protein and whole organism vaccines, particularly for complex pathogens that cause chronic infection. Previously, we have reported a promising lipid core peptide (LCP) vaccine delivery system that incorporates the antigen, carrier, and adjuvant in a single molecular entity. LCP vaccines have been used to deliver several peptide subunit-based vaccine candidates and induced high titre functional antibodies and protected against Group A streptococcus in mice. Herein, we have evaluated whether LCP constructs incorporating defined CD4+ and/or CD8+ T cell epitopes could induce epitope-specific T cell responses and protect against pathogen challenge in a rodent malaria model. We show that LCP vaccines failed to induce an expansion of antigen-specific CD8+ T cells following primary immunization or by boosting. We further demonstrated that the LCP vaccines induced a non-specific type 2 polarized cytokine response, rather than an epitope-specific canonical CD8+ T cell type 1 response. Cytotoxic responses of unknown specificity were also induced. These non-specific responses were able to protect against parasite challenge. These data demonstrate that vaccination with lipid core peptides fails to induce canonical epitope-specific T cell responses, at least in our rodent model, but can nonetheless confer non-specific protective immunity against Plasmodium parasite challenge.

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“…NALT has been proven to be a highly significant inductive site for activation of immunocompetent cells. NALT induces antigen-specific immune responses in the upper airways and other effector tissues of mucosa (Kurono et al 1999, Shimoda et al 2001, Zuercher et al 2002, Zaman et al 2010).…”

Section: Naltmentioning

confidence: 99%

“…NALT disposes all the immune cells in the body, which facilitate the induction of immune reactions of the mucosa against inhaled antigens. Furthermore, intranasal vaccination is also absorbing for its effective evoking of antigen-specific immune reactions in mucosal and systemic sections of human body as well (Kang et al 2009, Zaman et al 2010.…”

Section: Nalt and Vaccinationmentioning

confidence: 99%

Non-Reflex Defense Mechanisms of Upper Airway Mucosa: Possible Clinical Application

Pedan¹,

Janosova²,

Hajtman³

et al. 2020

Physiol Res

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The sinonasal mucosa has an essential role in defense mechanisms of the upper respiratory tract. The innate immune system presents the primary defense against noxious microorganisms followed by induction of the adaptive immune mechanisms as a consequence of the presence of pathogens. This well-known activation of adaptive immune system in response to presence of the antigen on mucosal surfaces is now broadly applicated in vaccinology research. Prevention of infectious diseases belongs to substantial challenges in maintaining the population health. Non-invasive, easily applicable mucosal vaccination purposes various research opportunities that could be usable in daily practice. However, the existence of multiple limitations such as rapid clearance of vaccine from nasal mucosa by means of mucociliary transport represents a great challenge in development of safe and efficient vaccines. Here we give an updated view on nasal functions with focus on nasal mucosal immunity and its potential application in vaccination in nearly future.

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Synthetic Polyacrylate Polymers as Particulate Intranasal Vaccine Delivery Systems for the Induction of Mucosal Immune Response

Cited by 21 publications

References 63 publications

Improvement of different vaccine delivery systems for cancer therapy

Improvement of different vaccine delivery systems for cancer therapy

Vaccination with Lipid Core Peptides Fails to Induce Epitope-Specific T Cell Responses but Confers Non-Specific Protective Immunity in a Malaria Model

Non-Reflex Defense Mechanisms of Upper Airway Mucosa: Possible Clinical Application

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