Synthetic peptide (DP1) functionalized graphene oxide: A biocompatible nanoformulation with broad-spectrum antibacterial and antibiofilm activity

Antimicrobial and Antibiofilm Potential of Green-Synthesized Graphene–Silver Nanocomposite against Multidrug-Resistant Nosocomial Pathogens

“…A similar trend was observed in the case of MLC values ranging from 125 to 500 µg/mL and from 62.5 to 250 µg/mL, respectively (Table 2). The C. glabrata ATCC 2001 strain demonstrated the lowest MIC values for AgNP and GO-AgNP, which is in sync with the findings previously reported in the literature [23].…”

“…The presence of less oxygen in GO-AgNP, as compared to pristine GO, indicates that GO has been successfully reduced to partially reduced GO. Similar findings have been recently reported in studies employing chemical-based methods [43] and green synthesis [23] of GBNs.…”

“…A similar trend was observed in the case of MLC values ranging from 125 to 500 µg/mL and from 62.5 to 250 µg/mL, respectively (Table 2). The C. glabrata ATCC 2001 strain demonstrated the lowest MIC values for AgNP and GO-AgNP, which is in sync with the findings previously reported in the literature [23]. Silver nanoparticles (AgNPs) are potent antimicrobial agents, with the potential to serve as surface coatings to enhance the properties of biomaterials [44].…”

“…Graphene oxide nanocomposites have been used for local antifungal activity, wound regeneration, and the targeting of specific infections in mucocutaneous tissues [22]. These have also been functionalized with antimicrobial peptides for imparting broad-spectrum antimicrobial and anti-fouling properties against nosocomial bacterial pathogens [23]. The effects of graphene oxide-silver nanoparticles have been investigated against Gram-positive and Gram-negative bacteria [24], as well as C. albicans [20].…”