Synthetic pathways to create asymmetric center at C1 position of 1-substituted-tetrahydro-β-carbolines – a review

Abstract

Chiral 1-substituted-THβC can be synthesized from l-tryptophan or tryptamine by Pictet–Spengler reaction and chiral auxiliary; also from substituted-DHβC by ATH reaction with chiral catalysts, asymmetric addition reaction, and enzymatic catalysis.