Synthetic nanostructured wollastonite: Composition, structure and “in vitro” biocompatibility investigation

Папынов, Е. К.; Shichalin, O.O.; Апанасевич, В. И.; Плехова, Н. Г.; Buravlev, I. Yu.; Zinoviev, S.V.; Mayorov, V. Yu.; Fedorets, A. N.; Merkulov, E. B.; Шлык, Д. Х.; Nepomnyushchaya, V.A.; Kornakova, Zlata E.; Afonin, I.S.; Evdokimov, I.O.; Korshunova, Oksana

doi:10.1016/j.ceramint.2021.04.258

Cited by 10 publications

(5 citation statements)

References 57 publications

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“…This feature is most probably related to the properties of fluorapatite, the main compound of the composite. It was reported that bulk density and porosity of FAP granules are 0.75 g/cm 3 and 52% in comparison with 0.55 g/cm 3 and 64% for HAP granules [31]. Volume of intrinsic pores in FAP and HAP granules was 0.36 cm 3 /g and 0.58 cm 3 /g, respectively [31].…”

Section: Resultsmentioning

confidence: 96%

“…Bioceramics based on calcium phosphate (CaP) are widely used in the field of bone regeneration, both in orthopaedics and dentistry, due to their good biocompatibility, bioactivity, osseointegration and osteoconduction [1]. Bone substitutes such as hydroxyapatite (HAP), tricalcium phosphates (α-and β-TCP) or bioactive glasses (BG) are therefore an alternative to auto-or allogeneic bone grafts [2,3]. These CaP materials, due to their characteristics, promote the migration of bone cells to their interior and the vascularization of the implant, which facilitates the process of bone tissue reconstruction [4,5].…”

Section: Introductionmentioning

confidence: 99%

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Highly Porous Fluorapatite/β-1,3-Glucan Composite for Bone Tissue Regeneration: Characterization and In-Vitro Assessment of Biomedical Potential

Borkowski

Przekora

Belcarz

et al. 2021

IJMS

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A novel fluorapatite/glucan composite (“FAP/glucan”) was developed for the treatment of bone defects. Due to the presence of polysaccharide polymer (β-1,3-glucan), the composite is highly flexible and thus very convenient for surgery. Its physicochemical and microstructural properties were evaluated using scanning electron microscopy (SEM), Fourier transform infrared spectroscopy (FTIR), mercury intrusion, mechanical testing and compared with the reference material, which was a hydroxyapatite/glucan composite (“HAP/glucan”) with hydroxyapatite granules (HAP) instead of FAP. It was found that FAP/glucan has a higher density and lower porosity than the reference material. The correlation between the Young’s modulus and the compressive strength between the materials is different in a dry and wet state. Bioactivity assessment showed a lower ability to form apatite and lower uptake of apatite-forming ions from the simulated body fluid by FAP/glucan material in comparison to the reference material. Moreover, FAP/glucan was determined to be of optimal fluoride release capacity for osteoblasts growth requirements. The results of cell culture experiments showed that fluoride-containing biomaterial was non-toxic, enhanced the synthesis of osteocalcin and stimulated the adhesion of osteogenic cells.

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Section: Resultsmentioning

confidence: 96%

Section: Introductionmentioning

confidence: 99%

Highly Porous Fluorapatite/β-1,3-Glucan Composite for Bone Tissue Regeneration: Characterization and In-Vitro Assessment of Biomedical Potential

Borkowski

Przekora

Belcarz

et al. 2021

IJMS

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“…Such works are limited in the literature. The promising use of synthetic wollastonite for this biomedical application is determined by its high biocompatibility, which was proved in the works [36][37][38][39], including our studies on in vitro and in vivo models [40,41] that evaluated its composite forms [42]. Second, the chemical composition of wollastonite is characterized by the presence of Ca 2+ ions, which will ensure the initiation of sorption interaction with 5-fluorouracil and its subsequent intercalation into the porous structure of the carrier.…”

Section: Introductionmentioning

confidence: 79%

Synthetic Calcium Silicate Biocomposite Based on Sea Urchin Skeleton for 5-Fluorouracil Cancer Delivery

et al. 2023

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Synthetic calcium silicates and phosphates are promising compounds for targeted drug delivery for the effective treatment of cancerous tumors, and for minimizing toxic effects on the patient’s entire body. This work presents an original synthesis of a composite based on crystalline wollastonite CaSiO3 and combeite Na4Ca4(Si6O18), using a sea urchin Mesocentrotus nudus skeleton by microwave heating under hydrothermal conditions. The phase and elemental composition and structure of the obtained composite were studied by XRF, REM, BET, and EDS methods, depending on the microwave heating time of 30 or 60 min, respectively, and the influence of thermo-oxidative post-treatment of samples. The role of the sea urchin skeleton in the synthesis was shown. First, it provides a raw material base (source of Ca2+) for the formation of the calcium silicate composite. Second, it is a matrix for the formation of its porous inorganic framework. The sorption capacity of the composite, with respect to 5-fluorouracil, was estimated, the value of which was 12.3 mg/L. The resulting composite is a promising carrier for the targeted delivery of chemotherapeutic drugs. The mechanism of drug release from an inorganic natural matrix was also evaluated by fitting its release profile to various mathematical models.

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“…This is due to its unique set of properties: nontoxicity, bioactivity, antimicrobial effect, structural porosity, low moisture absorption, corrosion resistance, bioresorption, and more [2][3][4][5]. An extensive list of known studies on the biocompatible properties of wollastonites in the world is presented in the research by Biswas et al [2], and is also reflected in the experimental studies [6]. A review of present studies on the toxicity of wollastonite is presented in [7].…”

Section: Introductionmentioning

confidence: 99%

CaSiO3-HAp Metal-Reinforced Biocomposite Ceramics for Bone Tissue Engineering

Папынов

Shichalin

Белов

et al. 2023

JFB

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Reconstructive and regenerative bone surgery is based on the use of high-tech biocompatible implants needed to restore the functions of the musculoskeletal system of patients. Ti6Al4V is one of the most widely used titanium alloys for a variety of applications where low density and excellent corrosion resistance are required, including biomechanical applications (implants and prostheses). Calcium silicate or wollastonite (CaSiO3) and calcium hydroxyapatite (HAp) is a bioceramic material used in biomedicine due to its bioactive properties, which can potentially be used for bone repair. In this regard, the research investigates the possibility of using spark plasma sintering technology to obtain new CaSiO3-HAp biocomposite ceramics reinforced with a Ti6Al4V titanium alloy matrix obtained by additive manufacturing. The phase and elemental compositions, structure, and morphology of the initial CaSiO3-HAp powder and its ceramic metal biocomposite were studied by X-ray fluorescence, scanning electron microscopy, energy-dispersive X-ray spectroscopy, and Brunauer–Emmett–Teller analysis methods. The spark plasma sintering technology was shown to be efficient for the consolidation of CaSiO3-HAp powder in volume with a Ti6Al4V reinforcing matrix to obtain a ceramic metal biocomposite of an integral form. Vickers microhardness values were determined for the alloy and bioceramics (~500 and 560 HV, respectively), as well as for their interface area (~640 HV). An assessment of the critical stress intensity factor KIc (crack resistance) was performed. The research result is new and represents a prospect for the creation of high-tech implant products for regenerative bone surgery.

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Synthetic nanostructured wollastonite: Composition, structure and “in vitro” biocompatibility investigation

Cited by 10 publications

References 57 publications

Highly Porous Fluorapatite/β-1,3-Glucan Composite for Bone Tissue Regeneration: Characterization and In-Vitro Assessment of Biomedical Potential

Highly Porous Fluorapatite/β-1,3-Glucan Composite for Bone Tissue Regeneration: Characterization and In-Vitro Assessment of Biomedical Potential

Synthetic Calcium Silicate Biocomposite Based on Sea Urchin Skeleton for 5-Fluorouracil Cancer Delivery

CaSiO3-HAp Metal-Reinforced Biocomposite Ceramics for Bone Tissue Engineering

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