Synthetic models for binuclear copper proteins

<b>Studies on some VO(IV), Ni(II) and Cu(II) complexes of non-symmetrical tetradentate Schiff-bases</b>

“…Schiff bases and its metal chelates have played important roles in the development of chemical industries through catalysis, substrate carriers and dyes [1][2][3][4][5][6]. Tucareso, a Schiff base-forming immunomodulator, is currently undergoing pilot phase I/II clinical trials as an immunopotentiator in chronic hepatitis B virus infection, HIV infection and malignant melanoma [7].…”

“…These ligands are widely studied because of their pronounced coordinating properties and stability [8][9]. A number of symmetrical Schiff bases and chelates have been reported [1][2][3][4][5][6][7][8][9][10][11][12][13][14][15], while comparatively little is known on synthesis and physico-chemical properties of asymmetric Schiff-base ligands and metal complexes [16][17][18][19][20]. Consequently, the aim of this work is to synthesize and characterize unsymmetrical Schiff-base ligands (derived from condensation of 1-phenyl-1,3-butanedione/2,4-pentanedione, ethylenediamine and 5-methoxy-2-hydroxy acetophenone) and their VO(IV), Ni(II) and Cu(II) complexes, in order to see the effect of the mixed π-electron ligand system and phenyl/methyl substituent on geometries and physico-chemical properties.…”

Distortion Isomerism of Cu(II) Chloride Adducts with Bis(2-benzimidazolyl)ethane. Synthesis, Characterization, X-ray Structures and Spectroscopy of Four Different Isomers

“…The coordination chemistry of the heterocyclic azoles acting as ligands in copper(II) compounds in the context of modelling biological systems has gained much interest in the past decades [1][2][3][4]. In this respect bis(2-benzimidazoles) have received much attention for their wide-ranging antivirus activity [5,6], their importance in selective ionexchange resins [7,8] and the possibility to form supramolecular aggregates with d 10 metal ions [9].…”

Mimics of copper proteins: structural and functional aspects

“…Dioxygen molecule can bind at these dinuclear copper active centers, and the structure elucidation of both the deoxygenated and the resulting oxygenated protein has been determined by spectral and EPR properties (Solomon et al 1996). Several groups studied model compounds mimicking the most relevant aspects of those species, specially insertion of oxygen atoms in substrates (Sorrell 1989, Monzani et al 1998, binding and activation of dioxygen in copper centers (Tolman 1997, Karlin et al 1997, Kitajima 1992.…”