Synthetic matrix of polyether-polyurethane as a biological platform for pancreatic regeneration

Pereira, Luciana Xavier; Viana, Celso Tarso Rodrigues; Orellano, Laura Alejandra Ariza; Almeida, Sebastião de Sousa; Vasconcelos, A.C.; Góes, Alfredo de Miranda; Birbrair, Alexander; Andrade, Sílvia Passos; Campos, Paula Peixoto

doi:10.1016/j.lfs.2017.03.015

Cited by 26 publications

(17 citation statements)

References 47 publications

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“…Among many methods used to construct 3 D scaffolds, similar to the extracellular matrix (ECM), electrospinning is an economic technique for the preparation of very thin polymer fibers, which can be easily applied in a lab or on an industrial scale [8]. Among many existing polymeric material sources that can be used to build cellular scaffolds, synthetic polymers are more appropriate choice than natural, since their structure and mechanical strength can be manipulated in the direction of the target tissues [8][9][10]. Polyethersulfone (PES) was used in this study as a synthetic polymer that used previously for blood purification and to generate other tissues during last decade [11][12][13][14].…”

Section: Introductionmentioning

confidence: 99%

Collagen coated electrospun polyethersulfon nanofibers improved insulin producing cells differentiation potential of human induced pluripotent stem cells

Mansour

Soleimanifar

Abazari

et al. 2018

Artificial Cells, Nanomedicine, and Biotechnology

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Section: Introductionmentioning

confidence: 99%

Collagen coated electrospun polyethersulfon nanofibers improved insulin producing cells differentiation potential of human induced pluripotent stem cells

Mansour

Soleimanifar

Abazari

et al. 2018

Artificial Cells, Nanomedicine, and Biotechnology

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“…The molecular processes that drive scar tissue formation in the skin remain poorly understood. Mesenchymal stem cells were proposed to be able to differentiate into extracellular matrix‐forming cells . As GPNMB may be involved in the recruitment of mesenchymal stem cells, it is possible that in the absence of GPNMB, scar formation is affected.…”

Section: Perspectives/future Directionsmentioning

confidence: 99%

Macrophage‐derived GPNMB accelerates skin healing

Silva

Prazeres

Paiva

et al. 2018

Experimental Dermatology

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Healing is a vital response important for the re-establishment of the skin integrity following injury. Delayed or aberrant dermal wound healing leads to morbidity in patients. The development of therapies to improve dermal healing would be useful. Currently, the design of efficient treatments is stalled by the lack of detailed knowledge about the cellular and molecular mechanisms involved in wound healing. Recently, using state-of-the-art technologies, it was revealed that macrophages signal via GPNMB to mesenchymal stem cells, accelerating skin healing. Strikingly, transplantation of macrophages expressing GPNMB improves skin healing in GPNMB-mutant mice. Additionally, topical treatment with recombinant GPNMB restored mesenchymal stem cells recruitment and accelerated wound closure in the diabetic skin. From a drug development perspective, this GPNMB is a new candidate for skin healing.

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“…The decisions of stem cells to continue quiescent, self‐renew, or differentiate are dependent on the interaction of these cells with other cells in their surrounding niches . Recently, multiple cell types have been identified as potential niche‐supporting cells for stem cells in the skin .…”

Section: Schwann Cells Plasticity In the Skinmentioning

confidence: 99%

“…The decisions of stem cells to continue quiescent, selfrenew, or differentiate are dependent on the interaction of these cells with other cells in their surrounding niches. [60][61][62][63][64][65][66][67][68] Recently, multiple cell types have been identified as potential niche-supporting cells for stem cells in the skin. 69 Nevertheless, how the composition of the cutaneous stem cell niche is affected during skin healing remains poorly understood.…”

Section: Schwann Cells Plasticity In the Skinmentioning

confidence: 99%

Role of Schwann cells in cutaneous wound healing

Silva

Leonel

Prazeres

et al. 2018

Wound Repair Regeneration

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Dermal wound healing is the process of repairing and remodeling skin following injury. Delayed or aberrant cutaneous healing poses a challenge for the health care system. The lack of detailed understanding of cellular and molecular mechanisms involved in this process hampers the development of effective targeted treatments. In a recent study, Parfejevs et al.-using state-of-the-art technologies, including in vivo sophisticated Cre/loxP techniques in combination with a mouse model of excisional cutaneous wounding-reveal that Schwann cells induce adult dermal wound healing. Strikingly, genetic ablation of Schwann cells delays wound contraction and closure, decreases myofibroblast formation, and impairs skin re-epithelization after injury. From a drug development perspective, Schwann cells are a new cellular candidate to be activated to accelerate skin healing. Here, we summarize and evaluate recent advances in the understanding of Schwann cells roles in the skin microenvironment.

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Synthetic matrix of polyether-polyurethane as a biological platform for pancreatic regeneration

Cited by 26 publications

References 47 publications

Collagen coated electrospun polyethersulfon nanofibers improved insulin producing cells differentiation potential of human induced pluripotent stem cells

Collagen coated electrospun polyethersulfon nanofibers improved insulin producing cells differentiation potential of human induced pluripotent stem cells

Macrophage‐derived GPNMB accelerates skin healing

Role of Schwann cells in cutaneous wound healing

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