“…One prominent exception is Davis's cage-shaped molecules, which selectively recognize carbohydrates exhibiting an all-equatorial array of polar functionalities in water (Ferrand et al, 2007(Ferrand et al, , 2009; Ke et al, 2012;Sookcharoenpinyo et al, 2012). However, despite advances in our understanding of factors contributing carbohydrate recognition (Asensio, et al, 2013;Francesconi et al, 2018;Roldó s et al, 2011;Tromans et al, 2019;Yang et al, 2011), there remains a general lack of synthetic small molecules that bind one specific carbohydrate under physiological conditions.…”