Synthetic hydrogels VI. Hydrogel composites as wound dressings and implant materials

Corkhill, Philip H.; Hamilton, Colin; Tighe, Brian

doi:10.1016/0142-9612(89)90002-1

Cited by 147 publications

(81 citation statements)

References 49 publications

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“…Their high water content usually makes them intrinsically cytocompatible and thus interesting for biomedical applications [1][2][3][4][5][6][7][8][9]. One general disadvantage of hydrogels that significantly affects their practical relevance is their usually low mechanical stability.…”

Section: Introductionmentioning

confidence: 99%

Tailored Macromolecules Versus Nanoparticles as Additives for Mechanical Reinforcement of NCO-sP(EO-stat-PO) Hydrogels

Harrass

Hildebrandt

Moeller

et al. 2013

Intelligent Hydrogels

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Hydrogels are three dimensional networks of hydrophilic polymers that exhibit high equilibrium water contents (up to 99 w/w-%) in aqueous environment. Beside the manifold advantages such as intrinsic biocompatibility, low friction and enormous swelling behaviour, this high water content also results in an intrinsically low mechanical stability. Different reinforcement strategies have been developed that rely on the strengthening by a second component. In this study we present the improvement of six arm star-shaped poly(ethylene oxide-stat-propylene oxide) (sPEOPO) primary networks by two different strategies: incorporation of amino-functionalized silica nanoparticles (nanocomposites, NC) and generation of interpenetrating networks (IPNs) by addition of tailored linear triblock copolymers. The compression moduli and mechanical stress-at-break of both hydrogel systems are compared and discussed. In comparison to sPEOPO, the NC hydrogels demonstrate a strengthening effect with a 2.5 times higher compression stress-at-break whereas the IPN increases the modulus up to a factor of 1.5.

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Section: Introductionmentioning

confidence: 99%

Tailored Macromolecules Versus Nanoparticles as Additives for Mechanical Reinforcement of NCO-sP(EO-stat-PO) Hydrogels

Harrass

Hildebrandt

Moeller

et al. 2013

Intelligent Hydrogels

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show abstract

“…[6][7][8] On account of their inertness and biocompatibility, hydrogels have been examined for a wide range of biomedical applications as soft contact lenses, wound dressing and implant materials. [9,10] Furthermore, the ability to release entrapped solutes in aqueous media makes hydrogels good carriers for a sustained and/or a controlled delivery of a variety of pharmacological agents ranging from small molecular weight compounds to macromolecular and protein drugs. [11][12][13][14][15][16][17] In efforts to develop new polymer materials suitable for pharmaceutical applications, our interest is focused on the preparation of polyaminoacidic derivatives, such as a,b-polyasparthydrazide (PAHy) synthetized by the reaction of a polysuccinimide (PSI) with hydrazine.…”

Section: Introductionmentioning

confidence: 99%

Novel hydrogels based on a polyasparthydrazide. Synthesis and characterization

Pitarresi¹,

Cavallaro²,

Carlisi³

et al. 2000

Macromol. Chem. Phys.

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α,β‐polyasparthydrazide (PAHy), a synthetic water‐soluble biocompatible polymer, was chemically crosslinked with ethyleneglycol diglycidylether (EGDGE), in order to obtain water swellable microparticles. These were characterized by means of FT‐IR spectrophotometry and by means of particle size distribution analysis. The mean pore size of the prepared gels at various crosslinking ratios and the fractal dimensions were determined by light scattering measurements. Swelling measurements gave evidence of the high affinity of PAHy‐EGDGE microparticles towards aqueous media at different pH values. The physical state of the prepared networks was evaluated by means of X‐rays diffractometry and thermal analysis. A peculiar effect of the degree of crosslinking on the glass transition temperature (Tg) value was shown. In vitro chemical and enzymatic stability studies suggested that the prepared samples do not undergo any degradation after treatment at pH 1, 7.4 and 10 as well as after incubation with enzymes such as pepsin and α‐chymotrypsin.

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“…Hydrogel polymers, such as polysaccharides and those derived from polymers and copolymers of methacrylic esters containing at least one hydroxyl group in the side chain, possess excellent biocompatibilities [ 13. Biomedical applications of these hydrogel polymers include soft contact lenses [2], implant materials [3,4], and wound dressings [5]. They are very hydrophilic, chemically inert, and stable in living tissue.…”

Section: Introductionmentioning

confidence: 99%

Hydrogel polymer coating for capillary electrophoretic separation of proteins

Huang

Lee

1992

J Microcolumn Separations

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Abstract. Three hydrogel polymers, poly(2-hydroxypropylmethacrylate), poly(2-hydroxyethylmethacrylate) , and hydroxypropylcellulose, were coated and immobilized on fused silica capillary surfaces using three different methods, all involving modification of the surfaces before polymerization and/or cross-linking. Since the hydrogel polymers swelled in aqueous solution and allowed permeation of low-molecular-weight compounds, an equilibrated state was attained between the hydrogel polymer layers and the buffer solution, which eliminated the interactions between proteins and the capillary surface, and allowed highly efficient and reproducible capillary electrophoretic separations of both basic and acidic proteins. The experimental results indicated that silanol groups on the capillary surface were covered and phosphate anions were trapped in the coating layers, which produced defined, but reduced, electroosmotic flows when compared to uncoated capillaries. High resolution separations of ribonuclease B variants and cytochrome c proteins from different sources were obtained.

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Synthetic hydrogels VI. Hydrogel composites as wound dressings and implant materials

Cited by 147 publications

References 49 publications

Tailored Macromolecules Versus Nanoparticles as Additives for Mechanical Reinforcement of NCO-sP(EO-stat-PO) Hydrogels

Tailored Macromolecules Versus Nanoparticles as Additives for Mechanical Reinforcement of NCO-sP(EO-stat-PO) Hydrogels

Novel hydrogels based on a polyasparthydrazide. Synthesis and characterization

Hydrogel polymer coating for capillary electrophoretic separation of proteins

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