Abstract:Antibodies play critical roles in protection against infectious diseases and can be passively administered to protect patients. In the case of antibodies against glucuronoxylomannan (GXM), the major constituent of the Cryptococcus neoformans capsule, this results in protective, non-protective and disease enhancing outcomes. We sought to improve our basic understanding of these functionally different antibodies. Here we report a library of twenty-six synthetic GXM oligosaccharides, consisting of M2 (serotype A)… Show more
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