Synthetic Genes For Dynamic Regulation Of DNA‐Based Receptors
Daniela Sorrentino,
Simona Ranallo,
Eiji Nakamura
et al.
Abstract:We present a strategy to control dynamically the loading and release of molecular ligands from synthetic nucleic acid receptors using in vitro transcription. We demonstrate this by engineering three model synthetic DNA‐based receptors: a triplex‐forming DNA complex, an ATP‐binding aptamer, and a hairpin strand, whose ability to bind their specific ligands can be cotranscriptionally regulated (activated or inhibited) through specific RNA molecules produced by rationally designed synthetic genes. The kinetics of… Show more
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