Synthetic estrogen bioaccumulates and changes the behavior and biochemical biomarkers in adult zebrafish

Tamagno, Wagner Antonio; Sofiatti, Jéssica Reis de Oliveira; Alves, Carla; Sutorillo, Nathália Tafarel; Vanin, Ana Paula; Bilibio, Denise; Pompermaier, Aline; Barcellos, Leonardo José Gil

doi:10.1016/j.etap.2022.103857

Cited by 14 publications

(3 citation statements)

References 55 publications

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“…Although filtration systems are an option for treating collected water, these systems do not remove many contaminants. In addition, there are many reports of impacts on zebrafish behavior, physiology, reproduction, and development for drug residues (48,49) and agrochemicals (50) .…”

Section: Source Of Watermentioning

confidence: 99%

Good practices in the rearing and maintenance of zebrafish (Danio rerio) in Brazilian laboratories

et al. 2023

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Good Laboratory Practice (GLP) is a management quality control system that encompasses the organizational process and conditions under which non-clinical health and environmental studies are carried out. According to the World Health Organization, GLP must contain five topics: resources, characterization, rules, results, and quality control. This work aims to address a review according to WHO standards of implementing Good Laboratory Practices in zebrafish (Danio rerio) vivariums. Considering that the promotion of one health (animal, human, and environmental) associated with an education plan, protocols, and records are fundamental to guarantee the safety and integrity of employees, animals, and the environment as well as reliability in the results generated. In a way, Brazil still needs improvements related to the well-being of aquatic organisms (national laws, international agreements, corporate programs, and others), especially concerning its use in research and technological development. In this way, the implementation of GLPs provides valuable guidance for improving animal welfare and worker safety, facilitating the standardization of research.

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Section: Source Of Watermentioning

confidence: 99%

Good practices in the rearing and maintenance of zebrafish (Danio rerio) in Brazilian laboratories

et al. 2023

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“…Apesar dos sistemas de filtração serem uma opção para o tratamento da água captada, muitos contaminantes não são removidos por esses sistemas. Existem muitos relatos dos impactos sobre o comportamento, a fisiologia, a reprodução e o desenvolvimento do zebrafish tanto para resíduos de medicamentos (48,49) , quanto para agroquímicos (50) .…”

Section: Fonte Da áGuaunclassified

Boas práticas na criação e manutenção de zebrafish (Danio rerio) em laboratório no Brasil

et al. 2023

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Resumo As Boas Práticas de Laboratório (BPL) são um sistema de controle de qualidade gerencial que abrange o processo organizacional e as condições sob as quais os estudos não clínicos de saúde e meio ambiente são desenvolvidos. Conforme a Organização Mundial da Saúde (OMS) as BPL devem conter cinco tópicos: recursos, caracterização, regras, resultados e controle de qualidade. O objetivo deste trabalho foi apresentar uma revisão conforme o padrão da OMS para a implementação das BPL em biotério de zebrafish. Considerando que a promoção da saúde única (animal, humana e ambiental) associada a um plano de educação, protocolos e registros são fundamentais para garantir a segurança e a integridade dos trabalhadores/pesquisadores, animais e meio ambiente assim como confiabilidade nos resultados gerados. De certa forma o Brasil ainda necessita de melhorias relacionadas ao bem-estar de organismos aquáticos (leis nacionais, acordos internacionais, programas corporativos e outros); especialmente em relação à utilização deste na pesquisa e desenvolvimento tecnológico. Desta forma, a implementação de BPL fornece uma orientação valiosa para a melhoria do bem-estar animal, e segurança do trabalhador vindo a facilitar a padronização da pesquisa.

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“…There is broad literature revising how reproductive and social behavior are impaired by 17α-ethinylestradiol (EE2), an oral contraceptive that is found in wastewater and effluents ( 150 ). Exposure to EE2 has an anxiolytic effect in adult zebrafish ( 151 ) and reduces dominant male aggression, impairing dominance and their reproductive success in half of exposed fish ( 70 ). Moreover, EE2 reduces females’ court behavior toward males and may have severe implications on the reproductive success of exposed zebrafish populations ( 152 ).…”

Section: Sex Steroids and Agonistic Behaviormentioning

confidence: 99%

Social behaviors as welfare indicators in teleost fish

2023

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Animal welfare is a key issue not only for aquaculture industry and food production, but also for daily husbandry practices in research topics related to physiology in wild and farmed animals. In this context, teleost fish constitute interesting models to assess alternative welfare indicators because of their wide diversity in reproductive and social structures. Any framework for assessing teleost fish welfare needs to account for the physiological mechanisms involved in each species as a first step. A comprehensive approach should also take into account how these physiological and behavioral parameters can be altered by environmental enrichment considering the specific requirements in each case and identifying intrinsic biological characteristics of individual species. This review will show how cortisol and sex steroids regulate social behavior in teleost fish, and how different aspects of social behavior can be employed as welfare indicators according to specific characteristics in each case. This article will consider evidence in teleost fish, including cichlids, characids and cyprinids with different reproductive strategies and social structures (e.g., territorial social hierarchies or shoaling behavior). Neotropical species will be particularly emphasized. The main laboratory-based animal welfare indicators are cortisol, a classical stress hormone, together with sex steroids. Considering that the endocrine landscape is intrinsically related to social behavior, reproductive and agonistic behavioral traits such as aggression, anxiety and courtship are key elements to assess welfare under housing and culture conditions. This review highlights the importance of assessing physiological mechanisms and identifying behavioral characteristics in teleost fish, especially in Neotropical species, as a baseline to understand which environmental enrichment can improve animal welfare in each individual species.

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Synthetic estrogen bioaccumulates and changes the behavior and biochemical biomarkers in adult zebrafish

Cited by 14 publications

References 55 publications

Good practices in the rearing and maintenance of zebrafish (Danio rerio) in Brazilian laboratories

Good practices in the rearing and maintenance of zebrafish (Danio rerio) in Brazilian laboratories

Boas práticas na criação e manutenção de zebrafish (Danio rerio) em laboratório no Brasil

Social behaviors as welfare indicators in teleost fish

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