Synthetic Engineering of Spider Silk Fiber as Implantable Optical Waveguides for Low-Loss Light Guiding

Qiao, Xueguang; Qian, Zhi‐Gang; Li, Junjie; Sun, Honghao; Han, Yifeng; Xia, Xiao-Xia; Zhou, Jin; Wang, Chunlan; Wang, Yan

doi:10.1021/acsami.7b01752

Cited by 67 publications

(73 citation statements)

References 47 publications

(81 reference statements)

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“…Their exceptional optical properties such as broadband optical transparency from ultraviolet (UV) to near infrared (IR), nonlinear optical, and Pockles electro‐optic effects, combined with natural elongated morphology of self‐assembled peptide nanostructures (nanotubes, nanofibers, and nanotapes) make them promising for optical linear and nonlinear waveguiding . In contrast to well‐known biomaterials' counterparts applied in implantable photonics, for instance, silk fibers, polymers, hydrogels, and more, these peptide‐based nanostructures have significantly higher refractive index ≈1.6 providing strong optical confinement of peptide optical waveguides . Another key functional optical effect is a new phenomenon of intrinsic tunable visible fluorescence (FL) recently revealed in different bioinspired peptide nanostructures …”

Section: Introductionmentioning

confidence: 99%

Peptide Nanophotonics: From Optical Waveguiding to Precise Medicine and Multifunctional Biochips

Apter

Lapshina

Handelman

et al. 2018

Small

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Optical waveguiding phenomena found in bioinspired chemically synthesized peptide nanostructures are a new paradigm which can revolutionize emerging fields of precise medicine and health monitoring. A unique combination of their intrinsic biocompatibility with remarkable multifunctional optical properties and developed nanotechnology of large peptide wafers makes them highly promising for new biomedical light therapy tools and implantable optical biochips. This Review highlights a new field of peptide nanophotonics. It covers peptide nanotechnology and the fabrication process of peptide integrated optical circuits, basic studies of linear and nonlinear optical phenomena in biological and bioinspired nanostructures, and their passive and active optical waveguiding. It is shown that the optical properties of this generation of bio-optical materials are governed by fundamental biological processes. Refolding the peptide secondary structure is followed by wideband optical absorption and visible tunable fluorescence. In peptide optical waveguides, such a bio-optical effect leads to switching from passive waveguiding mode in native α-helical phase to an active one in the β-sheet phase. The found active waveguiding effect in β-sheet fiber structures below optical diffraction limit opens an avenue for the future development of new bionanophotonics in ultrathin peptide/protein fibrillar structures toward advanced biomedical nanotechnology.

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Section: Introductionmentioning

confidence: 99%

Peptide Nanophotonics: From Optical Waveguiding to Precise Medicine and Multifunctional Biochips

Apter

Lapshina

Handelman

et al. 2018

Small

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“…Native spider silk fibers are also able to deliver light in physiological liquid and in an integrated photonic chip. Through genetic engineering, producing spider silk proteins at a large scale becomes possible [55]. Recently, researchers have fabricated optical waveguides by exploiting genetically engineered spider silk proteins [55].…”

Section: Materials and Synthesismentioning

confidence: 99%

“…Through genetic engineering, producing spider silk proteins at a large scale becomes possible [55]. Recently, researchers have fabricated optical waveguides by exploiting genetically engineered spider silk proteins [55]. The refractive index ( n = 1.70) of these fibers is much higher than that of biological tissues ( n = 1.33–1.51).…”

Section: Materials and Synthesismentioning

confidence: 99%

“…In addition, with a low propagation loss of ~0.8 dB/cm lower than that of regenerative silkworm silk waveguides, these waveguides are capable of guiding and delivering light and energy into deep tissues. As represented in Figure 3f, after inserting the recombinant spider silk optical waveguide, the penetration length of the light into muscle increases from less than 1 cm to 3 cm [55]. …”

Section: Materials and Synthesismentioning

confidence: 99%

Section: Figurementioning

confidence: 99%

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Biocompatible and Implantable Optical Fibers and Waveguides for Biomedicine

Nazempour

Zhang

et al. 2018

Materials

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Optical fibers and waveguides in general effectively control and modulate light propagation, and these tools have been extensively used in communication, lighting and sensing. Recently, they have received increasing attention in biomedical applications. By delivering light into deep tissue via these devices, novel applications including biological sensing, stimulation and therapy can be realized. Therefore, implantable fibers and waveguides in biocompatible formats with versatile functionalities are highly desirable. In this review, we provide an overview of recent progress in the exploration of advanced optical fibers and waveguides for biomedical applications. Specifically, we highlight novel materials design and fabrication strategies to form implantable fibers and waveguides. Furthermore, their applications in various biomedical fields such as light therapy, optogenetics, fluorescence sensing and imaging are discussed. We believe that these newly developed fiber and waveguide based devices play a crucial role in advanced optical biointerfaces.

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Light‐Guiding Biomaterials for Biomedical Applications

Shabahang

Kim

Yun

2018

Adv Funct Materials

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Optical techniques used in medical diagnosis, surgery, and therapy require efficient and flexible delivery of light from light sources to target tissues. While this need is currently fulfilled by glass and plastic optical fibers, recent emergence of biointegrated approaches, such as optogenetics and implanted devices, call for novel waveguides with certain biophysical and biocompatible properties and desirable shapes beyond what the conventional optical fibers can offer. To this end, exploratory efforts have begun to harness various transparent biomaterials to develop waveguides that can serve existing applications better and enable new applications in future photomedicine. Here, we review the recent progress in this new area of research for developing biomaterial-based optical waveguides. We begin with a survey of biological light-guiding structures found in plants and animals, a source of inspiration for biomaterial photonics engineering. We describe natural and synthetic polymers and hydrogels that offer appropriate optical properties, biocompatibility, biodegradability, and mechanical flexibility have been exploited for light-guiding applications. Finally, we briefly discuss perspectives on biomedical applications that may benefit from the unique properties and functionalities of light-guiding biomaterials.

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Synthetic Engineering of Spider Silk Fiber as Implantable Optical Waveguides for Low-Loss Light Guiding

Cited by 67 publications

References 47 publications

Peptide Nanophotonics: From Optical Waveguiding to Precise Medicine and Multifunctional Biochips

Peptide Nanophotonics: From Optical Waveguiding to Precise Medicine and Multifunctional Biochips

Biocompatible and Implantable Optical Fibers and Waveguides for Biomedicine

Light‐Guiding Biomaterials for Biomedical Applications

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