Synthetic efforts toward the bicyclo[3.2.1]octane fragment of rhodojaponin III

Total Syntheses of Rhodomollins A and B

“…Grayanoids are a large class of structurally and biologically interesting diterpenoids isolated from the Ericaceae plants . Synthetic chemist have been attracted by their challenging and diverse architectures. − The groups of Matsumoto, Shirahama, Newhouse, Ding, Luo, Jia, and ours have accomplished the syntheses of 16 grayanoids. Among the grayanoids, a number of members feature an intriguing oxa -bicyclo­[3.2.1] core, such as mollanol A, grayanotoxin XV, rhodomollins A and B, and pieristoxin L (Figure ), that attracted our attention.…”

Quantitative Study on Anti-Pest Activity of Natural Products Based on Visualization Framework of Knowledge Graph

“…However, the chemical transformation and structure-activity relationship of lauryl alcohol needs further study. The main active constituents of the insecticide obtained from Rhododendron molle is tetracyclic diterpenes with rhodojaponin-III one of the more active components [114,115] . A pot experiment testing the efficacy of rhodojaponin-III against Spodoptera litura larvae showed that after treatment with a concentration of 500 g• mL −1 rhodojaponin-III, the population reduction rate of S. litura was 53.2%, 64.1%, and 79.7% at 1, 3 and 7 days after treatment, respectively.…”

Total synthesis of grayanane natural products

“…The missing transformations include the removal of the ketone on the C ring, epoxide reductive opening, formation of the B ring exo-olefin, and glycosylation. In 2021, Hong et al presented a synthetic effort focused on the synthesis of rhodojaponin III B-C rings [40]. The authors employed a Mn(III)-mediated intramolecular radical cyclization of an alkynyl ketone as the key step.…”