The recent spread of COVID-19 across the U.S. led to concerted efforts by states to "flatten the curve" through the adoption of stay-at-home mandates that encourage individuals to reduce travel and maintain social distance. Combining data on changes in travel activity with COVID-19 health outcomes and state policy adoption, we characterize nationwide changes in mobility patterns, isolate the portion attributable to statewide mandates, and link these reductions to changes in COVID-19 health outcomes. We find evidence of dramatic nationwide declines participants in the National Association for Business Economics Webinar for comments and suggestions. We thank Unacast for providing us access to the data on mobility measures. in mobility prior to any statewide mandates, beginning early in a state's outbreak.Once states adopt a mandate, we estimate further mandate-induced declines between 2.8 and 6.5 percentage points across methods. Using previous changes in mobility, we find significant effects on current mortality and morbidity, with 1% reductions in visits to non-essential businesses weeks prior being associated with 9.2 fewer deaths per 100 million per day, corresponding with over 74,000 lives saved nationwide for the months of March and April -nearly 1.3 times the actual deaths during these months. These averted deaths correspond with estimated economic benefits between $249-$745 billion for observed behavioral changes in March and April. These estimates represent a lower bound of direct health benefits, as they do not account for spillovers or undercounting of COVID-19 mortality. Our findings indicate that statewide policies reduced travel and helped attenuate the negative consequences of COVID-19. Further, substantial reductions in mobility prior to state-level policies convey important policy implications for re-opening. stay-at-home mandates is critical for understanding the benefit of making the considerable economic sacrifices required to enact such policies. Even before mandates limited economic activity, GDP forecasts suggested an economic contraction in the U.S. of 24% [42]. Concerns over these costs prompted comments from the executive branch regarding relaxation of restrictions and allowing non-essential businesses to reopen [52], prompting opposition from public health experts [31,43] and economists [13,36].Recent simulations provide further insight into the benefits of social distancing.While epidemiological models of the U.K. and U.S. suggest that techniques for mitigating exposure of those most at risk may drastically reduce peak load on the healthcare system and cut COVID-19 deaths by half, such techniques on their own might not be enough to prevent the healthcare system from being overwhelmed. Some argue that, in this case, a combination of social distancing, self-quarantine of infected people, and suspension of schools would need to be maintained until a vaccine is available to prevent a rebound [28]. Other experts call for widespread testing coupled with digital contact tracing as a means to re...