Synthetic cryptolepine inhibits DNA binding of NF-κB

Research Progress on the Antineoplastic Pharmacological Effects and Mechanisms of Litchi Seeds

“…However, a low expression of NF-κB is discovered in the normal cells and it shows a very limited impact on the normal cells function even if the inhibition works. Therefore, suppressing the NF-κB and main impact factors in the signal pathway are likely to be the new sensitivity-enhanced targets of litchi extract antitumor in future [22]. This part can be seen in CH2.…”

Mechanisms of anti-inflammatory property of Anacardium occidentale stem bark: Inhibition of NF-κB and MAPK signalling in the microglia

“…Quantification of nitrite accumulation in BV-2 cells was carried out as described earlier (Olajide et al, 2007). Cells were seeded in 96-well plates (2 Â 10 5 /200 ml/well), cultured for 2 days, and then incubated with or without LPS (100 ng/ml) in the absence or presence of ANE (25-100 mg/ml) for 24 h. As a parameter of NO synthesis, nitrite concentration was assessed in the supernatant of BV-2 cells by the Griess reaction with a commercially available kit (Promega, Southampton, UK).…”

Compromise between compactness of micelle and overlap integral toward Förster resonance energy transfer from an indoloquinoline derivative to fluorescein: A fluorometric study

“…These alkaloids belong to cryptolepine family and are natural products [3]. They show wide applications as anti-malarial [2], anti-microbial [4,5], anti-imflammatory [6], and anticancer agents [7]. Cryptolepines are also known to bind tightly to DNA and behave as typical intercalating agents [8][9][10].…”