Synthetic Colloids Attenuate Leukocyte-Endothelial Interactions by Inhibition of Integrin Function

Abstract

This study shows that synthetic colloids inhibit neutrophil adhesion by a neutrophil-dependent mechanism rather than interfering with endothelial cell activation. This suggests that inhibition of leukocyte sequestration by volume support is a common and transient phenomenon depending on the colloid concentration in plasma.

Effect of High- and Low-molecular-weight Low-substituted Hydroxyethyl Starch on Blood Coagulation during Acute Normovolemic Hemodilution in Pigs

“…Besides the extensively described volume restoring properties, HES seems to exert significant beneficial antiinflammatory effects, 34,35 such as a diminishment of polymorphonuclear neutrophil sequestration in multiple organs. 34,36 Recent studies have shown that the clinically relevant effect of HES on leukocyte sequestration depends on the regulation of the integrin function. 36 The duration of the antiinflammatory effect after HES administration thus may be largely determined by the intravascular elimination of the colloid.…”

“…34,36 Recent studies have shown that the clinically relevant effect of HES on leukocyte sequestration depends on the regulation of the integrin function. 36 The duration of the antiinflammatory effect after HES administration thus may be largely determined by the intravascular elimination of the colloid. 36 Contrary to these findings, no effect or an apparent proinflammatory action after HES administration has recently be shown by Lang et al 37 Additional studies evaluating the antiinflammatory effect of high-molecular-weight low-substituted HES solutions due to their probable longer intravascular confinement thus seem to be worthwhile.…”

Influence of Dextran-70 on Systemic Inflammatory Response and myocardial ischaemia-reperfusion following cardiac operations

“…The inhibition of leukocyteendothelium interaction already occurs in the pharmacological microdose of dextran, independently of the haemodilution effect [8]. On the basis of recently published experimental data, dextran inhibits neutrophil adhesion by a neutrophildependent mechanism, regulating integrin function rather than interfering with endothelial cell activation [23]. In the same Procalcitonin plasma levels before operation and 24 hours after cardiopulmonary bypass Procalcitonin plasma levels before operation and 24 hours after cardiopulmonary bypass.…”

Hydroxyethyl Starch Inhibits Endothelium-Derived Relaxation in Porcine Coronary Arteries

“…The investigation of the endothelial function in the context of inflammation remains dubious because a later report of the same study group [9] showed that HES inhibits neutrophil adhesion by a neutrophil-dependent mechanism rather than by interfering with endothelial cell activation. In addition, the anti-inflammatory effects of HES may be the result of an effective fluid resuscitation [25] .…”

“…The inhibition of blood coagulation and thrombocyte function by HES has been described in the literature [6] . Also, the effects on receptor expression of endothelial cells and cell migration through the endothelial layer have been investigated [7][8][9] , but the effects of HES on EDR are unknown.…”