Synthetic chalcones as potential anti-inflammatory and cancer chemopreventive agents

Anti-angiogenic activity of the flavonoid precursor 4-hydroxychalcone

“…These compounds could make a great contribution to the total daily intake of natural polyphenolics (Tomas-Barberan and Clifford, 2010), since they appear to possess potentially beneficial effects against various diseases (de Campos-Buzzi et al, 2006;Sharma et al, 2009). Indeed, they are associated with several biologically active properties, including anti-inflammatory (Hsieh et al, 2000;Won et al, 2005), anti-oxidative (Nerya et al, 2004), anti-fungal (Sivakumar et al, 2009a), anti-bacterial (Sivakumar et al, 2009b), chemo-preventive and anti-cancer activities (Ducki, 2007;Chua et al, 2010;Katsori and Hadjipavlou-Litina, 2009;Liu and Go, 2006;Modzelewska et al, 2006). Although there are an increasing number of articles relating the anti-cancer activities of chalcones, limited information is available about a possible anti-angiogenic activity of this class of compounds (Kang et al, 2010;Kim et al, 2010;Mojzis et al, 2008).…”

(E)-1-(2-Aminophenyl)-3-(4-chlorophenyl)prop-2-en-1-one

“…Chalcones are synthetic or naturally occurring α,β-unsaturated diaryl ketones which have shown a wide spectrum of biological activities as anti-tubercular [1], anti-inflammatory [2], antimalarial [3], antibacterial [4], antifungal [5], and mainly antitumor agents [6]. These compounds have also been widely used as precursors for diverse synthetic approaches, mainly in the synthesis of hererocyclic compounds [7,8].…”

Novel tetrazole and cyanamide derivatives as inhibitors of cyclooxygenase-2 enzyme: design, synthesis, anti-inflammatory evaluation, ulcerogenic liability and docking study

“…On the other hand, pyridine scaffold [23][24][25] was the base of many bioactive molecules especially anti-inflammatory agents. Moreover, pyrazoline ring [26][27][28][29] , hydrazone functionality 30 and chalcones [31][32][33] are attractive motifs for anti-inflammatory drugs. Non-steroidal anti-inflammatory drugs (NSAIDs) are of great importance in the treatment of inflammation and pain.…”