Abstract:The use of synthetic biomarkers is an emerging technique to improve disease diagnosis. Here, we report a novel design strategy that uses analyte-responsive acetaminophen (APAP) to expand the catalogue of analytes available for synthetic biomarker development. As proof-of-concept, we designed hydrogen peroxide (H O )-responsive APAP (HR-APAP) and succeeded in H O detection with cellular and animal experiments. In fact, for blood samples following HR-APAP injection, we demonstrated that the plasma concentration … Show more
“…PB-DNA 1 has selectivity for H 2 O 2 over other reactive oxygen species (ROS). Extracellular ROS 18 generated almost no signal derived from NH 2 -DNA 1 (Fig. S3, ESI†).…”
We developed a system to detect multiple target biomolecules through sensing motif-tethered oligodeoxynucleotides. DNA-based molecular probes gave the primary amine motif upon reaction with the target biomolecules, gluthione (GSH) and...
“…PB-DNA 1 has selectivity for H 2 O 2 over other reactive oxygen species (ROS). Extracellular ROS 18 generated almost no signal derived from NH 2 -DNA 1 (Fig. S3, ESI†).…”
We developed a system to detect multiple target biomolecules through sensing motif-tethered oligodeoxynucleotides. DNA-based molecular probes gave the primary amine motif upon reaction with the target biomolecules, gluthione (GSH) and...
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