Synthetic Biology‐based Construction of Unnatural Perylenequinones with Improved Photodynamic Anticancer Activities
Zengping Su,
Baodang Guo,
Huibin Xu
et al.
Abstract:The construction of structural complexity and diversity of natural products is crucial for drug discovery and development. To overcome high dark toxicity and poor photostability of natural photosensitizer perylenequinones (PQs) for photodynamic therapy, herein, we aim to introduce the structural complexity and diversity to biosynthesize the desired unnatural PQs in fungus Cercospora through synthetic biology‐based strategy. Thus, we first elucidate the intricate biosynthetic pathways of class B PQs and reveal … Show more
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