Abstract:The production of high-quality recombinant proteins is critical
to maintaining a continuous supply of biopharmaceuticals, such as
therapeutic antibodies. Engineering mammalian cell factories presents a
number of limitations typically associated with proteotoxic stress
induced upon aberrant accumulation of off-pathway protein folding
intermediates, which eventually culminate with the induction of
apoptosis. Recent progress in mammalian synthetic biology provides
unique opportunities to endow cells with programm… Show more
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.